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The coevolutionary mosaic of bat betacoronavirus emergence risk.
Forero-Muñoz, Norma R; Muylaert, Renata L; Seifert, Stephanie N; Albery, Gregory F; Becker, Daniel J; Carlson, Colin J; Poisot, Timothée.
Afiliación
  • Forero-Muñoz NR; Département de Sciences Biologiques, Université de Montréal, 1375 Avenue Thérèse-Lavoie-Roux, Montréal (Québec) H2V 0B3, Canada.
  • Muylaert RL; Québec Centre for Biodiversity Sciences.
  • Seifert SN; Molecular Epidemiology and Public Health Laboratory, School of Veterinary Science, Massey University, New Zealand.
  • Albery GF; Paul G. Allen School for Global Health, Washington State University, Pullman, WA, United States.
  • Becker DJ; Department of Biology, Georgetown University, Washington, DC, USA.
  • Carlson CJ; Department of Biology, University of Oklahoma, Norman, OK, USA.
  • Poisot T; Department of Biology, Georgetown University, Washington, DC, USA.
Virus Evol ; 10(1): vead079, 2024.
Article en En | MEDLINE | ID: mdl-38361817
ABSTRACT
Pathogen evolution is one of the least predictable components of disease emergence, particularly in nature. Here, building on principles established by the geographic mosaic theory of coevolution, we develop a quantitative, spatially explicit framework for mapping the evolutionary risk of viral emergence. Driven by interest in diseases like Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus disease 2019 (COVID-19), we examine the global biogeography of bat-origin betacoronaviruses, and find that coevolutionary principles suggest geographies of risk that are distinct from the hotspots and coldspots of host richness. Further, our framework helps explain patterns like a unique pool of merbecoviruses in the Neotropics, a recently discovered lineage of divergent nobecoviruses in Madagascar, and-most importantly-hotspots of diversification in southeast Asia, sub-Saharan Africa, and the Middle East that correspond to the site of previous zoonotic emergence events. Our framework may help identify hotspots of future risk that have also been previously overlooked, like West Africa and the Indian subcontinent, and may more broadly help researchers understand how host ecology shapes the evolution and diversity of pandemic threats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Virus Evol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Virus Evol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido