Your browser doesn't support javascript.
loading
Molecular Imaging of Acute Graft-Versus-Host Disease.
Bernardi, Chiara; Garibotto, Valentina; Mobashwera, Behnaz; Negrin, Robert S; Alam, Israt S; Simonetta, Federico.
Afiliación
  • Bernardi C; Division of Hematology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.
  • Garibotto V; Translational Research Center for Oncohematology, Department of Medicine, University of Geneva, Geneva, Switzerland.
  • Mobashwera B; Translational Research Center for Oncohematology, Department of Medicine, University of Geneva, Geneva, Switzerland.
  • Negrin RS; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
  • Alam IS; CIBM Center for Biomedical Imaging, Geneva, Switzerland.
  • Simonetta F; Department of Hematology, Southampton General Hospital, University Hospital Southampton, Southampton, United Kingdom.
J Nucl Med ; 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38360050
ABSTRACT
Noninvasive molecular imaging of acute graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation has great potential to detect GvHD at the early stages, aid in grading of the disease, monitor treatment response, and guide therapeutic decisions. Although the specificity of currently available tracers appears insufficient for clinical GvHD diagnosis, recently, several preclinical studies have identified promising new imaging agents targeting one or more biologic processes involved in GvHD pathogenesis, ranging from T-cell activation to tissue damage. In this review, we summarize the different approaches reported to date for noninvasive detection of GvHD using molecular imaging with a specific focus on the use of PET. We discuss possible applications of molecular imaging for the detection of GvHD in the clinical setting, as well as some of the predictable challenges that are faced during clinical translation of these approaches.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos