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ASICs mediate fast excitatory synaptic transmission for tactile discrimination.
Yamada, Akihiro; Ling, Jennifer; Yamada, Ayaka I; Furue, Hidemasa; Gu, Jianguo G.
Afiliación
  • Yamada A; Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Ling J; Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Yamada AI; Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Furue H; Department of Neurophysiology, Hyogo Medical University, Nishinomiya 663-8501, Japan.
  • Gu JG; Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: jianguogu@uabmc.edu.
Neuron ; 112(8): 1286-1301.e8, 2024 Apr 17.
Article en En | MEDLINE | ID: mdl-38359825
ABSTRACT
Tactile discrimination, the ability to differentiate objects' physical properties such as texture, shape, and edges, is essential for environmental exploration, social interaction, and early childhood development. This ability heavily relies on Merkel cell-neurite complexes (MNCs), the tactile end-organs enriched in the fingertips of humans and the whisker hair follicles of non-primate mammals. Although recent studies have advanced our knowledge on mechanical transduction in MNCs, it remains unknown how tactile signals are encoded at MNCs. Here, using rodent whisker hair follicles, we show that tactile signals are encoded at MNCs as fast excitatory synaptic transmission. This synaptic transmission is mediated by acid-sensing ion channels (ASICs) located on the neurites of MNCs, with protons as the principal transmitters. Pharmacological inhibition or genetic deletion of ASICs diminishes the tactile encoding at MNCs and impairs tactile discrimination in animals. Together, ASICs are required for tactile encoding at MNCs to enable tactile discrimination in mammals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Merkel / Canales Iónicos Sensibles al Ácido Tipo de estudio: Prognostic_studies Límite: Animals / Child, preschool / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Merkel / Canales Iónicos Sensibles al Ácido Tipo de estudio: Prognostic_studies Límite: Animals / Child, preschool / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos