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CEBPA double mutations associated with ABO antigen weakness in hematologic diseases.
Choi, Seung Jun; Kim, Hyun Kyung; Suh, Eun Jung; Kwon, Soon Sung; Shin, Saeam; Lee, Seung-Tae; Kim, Sinyoung.
Afiliación
  • Choi SJ; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Kim HK; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Suh EJ; Department of Obstetrics and Gynecology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
  • Kwon SS; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Shin S; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Lee ST; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Kim S; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Blood Adv ; 8(6): 1487-1493, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38359363
ABSTRACT
ABSTRACT ABO antigen weakness is rarely observed in ABO typing for transfusion. Hematologic diseases and associated gene mutations have been suggested as potential causes of this phenomenon, yet the precise etiology has not been elucidated. Through ABO typing and genetic analysis data conducted over 7 years, we have reconfirmed the association between ABO antigen weakness and hematologic diseases, especially acute myeloid leukemia (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.12-5.83) and myelodysplastic syndrome (OR, 6.94; 95% CI, 2.86-16.83), and discovered previously unidentified candidate genes, CEBPA (OR, 43.70; 95% CI, 18.12-105.40), NRAS (OR, 3.37; 95% CI, 1.46-7.79), U2AF1 (OR, 8.12; 95% CI, 2.86-23.03), and PTPN11 (OR, 4.52; 95% CI, 1.51-13.50), seemingly associated with this phenomenon. Among these, CEBPA double mutations displayed a significant association, with ABO antigen weakness being observed in 20 of the 25 individuals (80.0%) possessing these mutations. From this study, new factors associated with ABO antigen weakness have been identified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos