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Comparing high definition transcranial direct current stimulation to left temporoparietal junction and left inferior frontal gyrus for logopenic primary progressive aphasia: A single-case study.
Crowley, Samuel J; Iordan, Alexandru D; Rinna, Kayla; Barmada, Sami; Hampstead, Benjamin M.
Afiliación
  • Crowley SJ; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan Medicine, Ann Arbor, MI, USA.
  • Iordan AD; Mental Health Service, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.
  • Rinna K; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan Medicine, Ann Arbor, MI, USA.
  • Barmada S; Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
  • Hampstead BM; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan Medicine, Ann Arbor, MI, USA.
Neuropsychol Rehabil ; : 1-26, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38358112
ABSTRACT
Logopenic variant primary progressive aphasia (lvPPA) is characterized by word-finding deficits and phonologic errors in fluent speech. Transcranial direct current stimulation (tDCS) targeting either left temporoparietal junction (TPJ) or left inferior frontal gyrus (IFG) show evidence of improving language function in lvPPA. The present case study evaluated the effects of two separate rounds of high definition tDCS (HD-tDCS) (4 mA; 30 sessions) on language and functional neuroimaging in a 57-year-old woman with lvPPA. Stimulation was centred on two different regions across rounds (1) left TPJ, and (2) left (IFG). Results showed an improved proportion of content to floorholder words during a naturalistic speech task through both rounds as well as change in confrontation naming after TPJ (improvement) and IFG (worsened) stimulation. fMRI connectivity during task showed left lateralized positive correlations following round 1 and anti-correlations with components of the default mode network following round 2. Resting state segregation of a language-associated functional network increased following both rounds, and task-based segregation of the same network increased following IFG stimulation. These results suggest that stimulation to both regions using HD-tDCS may improve language function in lvPPA, while simultaneously eliciting widespread changes beyond the targeted area in neuronal activity and functional connectivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuropsychol Rehabil Asunto de la revista: NEUROLOGIA / PSICOLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuropsychol Rehabil Asunto de la revista: NEUROLOGIA / PSICOLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido