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No-reflow after stroke reperfusion therapy: An emerging phenomenon to be explored.
Jia, Milan; Jin, Feiyang; Li, Sijie; Ren, Changhong; Ruchi, Mangal; Ding, Yuchuan; Zhao, Wenbo; Ji, Xunming.
Afiliación
  • Jia M; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Jin F; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Li S; Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Ren C; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Ruchi M; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
  • Ding Y; Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
  • Zhao W; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Ji X; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
CNS Neurosci Ther ; 30(2): e14631, 2024 02.
Article en En | MEDLINE | ID: mdl-38358074
ABSTRACT
In the field of stroke thrombectomy, ineffective clinical and angiographic reperfusion after successful recanalization has drawn attention. Partial or complete microcirculatory reperfusion failure after the achievement of full patency of a former obstructed large vessel, known as the "no-reflow phenomenon" or "microvascular obstruction," was first reported in the 1960s and was later detected in both experimental models and patients with stroke. The no-reflow phenomenon (NRP) was reported to result from intraluminal occlusions formed by blood components and extraluminal constriction exerted by the surrounding structures of the vessel wall. More recently, an emerging number of clinical studies have estimated the prevalence of the NRP in stroke patients following reperfusion therapy, ranging from 3.3% to 63% depending on its evaluation methods or study population. Studies also demonstrated its detrimental effects on infarction progress and neurological outcomes. In this review, we discuss the research advances, underlying pathogenesis, diagnostic techniques, and management approaches concerning the no-reflow phenomenon in the stroke population to provide a comprehensive understanding of this phenomenon and offer references for future investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Fenómeno de no Reflujo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Fenómeno de no Reflujo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido