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Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders.
Guimond, Synthia; Alftieh, Ahmad; Devenyi, Gabriel A; Mike, Luke; Chakravarty, M Mallar; Shah, Jai L; Parker, David A; Sweeney, John A; Pearlson, Godfrey; Clementz, Brett A; Tamminga, Carol A; Keshavan, Matcheri.
Afiliación
  • Guimond S; Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada.
  • Alftieh A; Department of Psychoeducation and Psychology, Université du Québec en Outaouais, Gatineau, QC, Canada.
  • Devenyi GA; Department of Psychiatry, Massachusetts Mental Health Center and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Mike L; Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada.
  • Chakravarty MM; Department of Psychiatry, McGill University, Montréal, QC, Canada.
  • Shah JL; Douglas Mental Health University Institute, Verdun, QC, Canada.
  • Parker DA; Department of Psychiatry, Massachusetts Mental Health Center and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sweeney JA; Department of Psychiatry, McGill University, Montréal, QC, Canada.
  • Pearlson G; Douglas Mental Health University Institute, Verdun, QC, Canada.
  • Clementz BA; Department of Biomedical Engineering, McGill University Montréal, QC, Canada.
  • Tamminga CA; Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada.
  • Keshavan M; Department of Psychiatry, McGill University, Montréal, QC, Canada.
Psychol Med ; 54(8): 1835-1843, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38357733
ABSTRACT

BACKGROUND:

Enlarged pituitary gland volume could be a marker of psychotic disorders. However, previous studies report conflicting results. To better understand the role of the pituitary gland in psychosis, we examined a large transdiagnostic sample of individuals with psychotic disorders.

METHODS:

The study included 751 participants (174 with schizophrenia, 114 with schizoaffective disorder, 167 with psychotic bipolar disorder, and 296 healthy controls) across six sites in the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium. Structural magnetic resonance images were obtained, and pituitary gland volumes were measured using the MAGeT brain algorithm. Linear mixed models examined between-group differences with controls and among patient subgroups based on diagnosis, as well as how pituitary volumes were associated with symptom severity, cognitive function, antipsychotic dose, and illness duration.

RESULTS:

Mean pituitary gland volume did not significantly differ between patients and controls. No significant effect of diagnosis was observed. Larger pituitary gland volume was associated with greater symptom severity (F = 13.61, p = 0.0002), lower cognitive function (F = 4.76, p = 0.03), and higher antipsychotic dose (F = 5.20, p = 0.02). Illness duration was not significantly associated with pituitary gland volume. When all variables were considered, only symptom severity significantly predicted pituitary gland volume (F = 7.54, p = 0.006).

CONCLUSIONS:

Although pituitary volumes were not increased in psychotic disorders, larger size may be a marker associated with more severe symptoms in the progression of psychosis. This finding helps clarify previous inconsistent reports and highlights the need for further research into pituitary gland-related factors in individuals with psychosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis / Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar / Imagen por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis / Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar / Imagen por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido