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Postpartum resolution of hypertension, proteinuria and acute kidney injury among women with preeclampsia and severe features at Mulago National Referral Hospital, Uganda: a cohort study.
Muteke, Kasereka; Musaba, Milton W; Mukunya, David; Beyeza, Jolly; Wandabwa, Julius N; Kiondo, Paul.
Afiliación
  • Muteke K; Department of Obstetrics and gynecology, College of Health Sciences, Makerere University, P.O BOX 7072, Kampala, Uganda.
  • Musaba MW; Department of Obstetrics and Gynecology, Faculty of Health Sciences, Busitema University, P.O Box 1460, Mbale, Uganda.
  • Mukunya D; Department of Public and Community Health, Faculty of Health Sciences, Busitema University, P.O Box 1460, Mbale, Uganda.
  • Beyeza J; Department of Obstetrics and gynecology, College of Health Sciences, Makerere University, P.O BOX 7072, Kampala, Uganda.
  • Wandabwa JN; Department of Obstetrics and Gynecology, Mulago National Referral Hospital, P.O Box 7051, Kampala, Uganda.
  • Kiondo P; Department of Obstetrics and Gynecology, Faculty of Health Sciences, Busitema University, P.O Box 1460, Mbale, Uganda.
Afr Health Sci ; 23(3): 27-36, 2023 Sep.
Article en En | MEDLINE | ID: mdl-38357176
ABSTRACT

Background:

The resolution of hypertension, proteinuria and AKI postpartum among women with preeclampsia is not well documented in Uganda.

Objective:

To determine the time to resolution of hypertension, proteinuria and AKI postpartum until 6 weeks among women with preeclampsia in Mulago Hospital, Uganda.

Methods:

Between August 2017 and April 2018, we measured blood pressure, urine protein and serum creatinine on days 1,7,21 and 42 postpartum among 86 women with preeclampsia. The primary outcomes were time to the resolution of hypertension, proteinuria and AKI. We fitted accelerated failure models using Stata 17's stintreg. command with a log normal distribution and obtained time ratios of selected exposures on time to resolution of hypertension, proteinuria and AKI intervals.

Results:

The median time to resolution of hypertension, proteinuria and AKI was seven (7) days (Inter quartile range, IQR 1-21). The time to resolution of hypertension among primiparous women was 3.5 times that of multiparous women [TR 3.5, 95%CI 1.1, 11.3]. No differences were observed in resolution of hypertension, proteinuria and acute kidney injury.

Conclusion:

The time to resolution of hypertension, proteinuria and AKI was seven days. We recommend larger studies with longer follow-up beyond six-weeks postpartum to inform revision of our guidelines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Lesión Renal Aguda / Hipertensión Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Afr Health Sci Asunto de la revista: MEDICINA / SERVICOS DE SAUDE Año: 2023 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Uganda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Lesión Renal Aguda / Hipertensión Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Afr Health Sci Asunto de la revista: MEDICINA / SERVICOS DE SAUDE Año: 2023 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Uganda