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Outcomes of liver diseases in pregnant females: A study from a tertiary care medical center in Pakistan.
Butt, Nazish; Ali, Sabir; Yasmeen, Haleema; Mumtaz, Khalid.
Afiliación
  • Butt N; Nazish Butt, FCPS. Gastroenterology Department, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Ali S; Sabir Ali, MBBS. Gastroenterology Department, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Yasmeen H; Haleema Yasmeen, FCPS. Gastroenterology Department, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
  • Mumtaz K; Khalid Mumtaz, FCPS (Med), FCPS (GI), MSc Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University, Columbus, United States.
Pak J Med Sci ; 40(3Part-II): 284-290, 2024.
Article en En | MEDLINE | ID: mdl-38356828
ABSTRACT

Objective:

To determine the etiologies and outcomes of liver disease in pregnancy in a developing country.

Method:

A total of 336 consecutive pregnant women with liver disease were included in this prospective cohort study conducted at the Department of Gastroenterology, Jinnah Postgraduate Medical Center, Karachi from August 2019 to August 2021. Patients' baseline demographic, clinical, and laboratory data and outcomes were collected on a pre-designed questionnaire.

Results:

Among all the pregnant females, the most common liver disease was acute hepatitis E virus (HEV) infection (37.2%), followed by preeclampsia (PEC)/eclampsia (EC), hemolysis, elevated liver enzymes & low platelets (HELLP) syndrome, and hyperemesis gravidarum (HG). The most common maternal complications were fulminant hepatic failure (FHF) in 14.9% and placental abruption in 11.0%. Fetal complications included intrauterine death (IUD) in 20.8% and preterm birth in 8.6%. The maternal and neonatal mortality rates were 11.6% and 39.6%, respectively. Among the predictors, low maternal weight, low body mass index (BMI), and low hemoglobin (Hb) were associated with increased maternal mortality. Low fetal weight, height, maternal systolic blood pressure (SBP), and low maternal Hb were independent predictors of fetal mortality.

Conclusion:

In our cohort of pregnant females in a tertiary care medical center, acute HEV was the most common liver disease, followed by PEC/EC, HELLP, and HG. Maternal and fetal deaths were alarming in this group of patients and demanded careful management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pak J Med Sci Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pak J Med Sci Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán