Your browser doesn't support javascript.
loading
DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders.
Li, Huan; Li, Wenhui; Gao, Yijun; Li, Junqi; Zeng, Xiliang; Lin, Jiaming; Xie, Xiaoyan; Ling, Tianyou.
Afiliación
  • Li H; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
  • Li W; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
  • Gao Y; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
  • Li J; Changsha JianLu Medical Laboratory Co, 18 Luyun Road, Changsha 410006, People's Republic of China.
  • Zeng X; Changsha JianLu Medical Laboratory Co, 18 Luyun Road, Changsha 410006, People's Republic of China.
  • Lin J; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
  • Xie X; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
  • Ling T; Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
J Cancer ; 15(5): 1182-1190, 2024.
Article en En | MEDLINE | ID: mdl-38356714
ABSTRACT

Background:

Oral Submucosal Fibrosis (OSF) and Oral Leukoplakia (OLK) are well-known oral potentially malignant disorders, and cases of Oral Submucosal Fibrosis concomitant Oral Leukoplakia (OSF+OLK) are now being reported clinically. DNA image cytometry is an objective and non-invasive method for monitoring the risk of precancerous lesions in the oral cavity.

Methods:

A total of 111 patients with clinically characterized oral mucosal lesions underwent simultaneous and independent histopathological and DNA imaging cytometry assessments. Clinical data were also collected for each patient.

Results:

The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.003) for OLK. The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.035) for OSF+OLK. The differences of DNA content abnormality in age, sex, dietary habit, smoking, and alcohol intake were not observed in OLK and OSF+OLK. The study indicates an association between DNA content abnormality and pathological examination in OSF+OLK ( χ2 test, P = 0.007). OLK showed higher sensitivity and specificity than OSF, while the sensitivity and specificity of OSF+OLK are higher than OLK only and OSF only.

Conclusion:

DNA image cytometry can be utilized as an adjunctive device for the initial detection of oral potentially malignant disorders that require further clinical management.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Australia