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The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder.
Yulug, Burak; Ayyildiz, Sevilay; Sayman, Dila; Karaca, Ramazan; Ipek, Lutfiye; Cankaya, Seyda; Salar, Ali Behram; Ayyildiz, Behcet; Mikuta, Christian; Yagci, Nilay; Oktem, Ece Ozdemir; Ozsimsek, Ahmet; Velioglu, Halil Aziz; Hanoglu, Lutfu.
Afiliación
  • Yulug B; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
  • Ayyildiz S; Department of Neurology and Neuroscience Istanbul Medipol University Istanbul Turkey.
  • Sayman D; School of Medicine Department of Neuroradiology Technical University of Munich Munich Germany.
  • Karaca R; School of Medicine TUM-NIC Neuroimaging Center Technical University of Munich Munich Germany.
  • Ipek L; Anatomy PhD Program Graduate School of Health Sciences Kocaeli University Istanbul Turkey.
  • Cankaya S; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
  • Salar AB; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
  • Ayyildiz B; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
  • Mikuta C; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
  • Yagci N; Functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA) Istanbul Medipol University Istanbul Turkey.
  • Oktem EO; Anatomy PhD Program Graduate School of Health Sciences Kocaeli University Istanbul Turkey.
  • Ozsimsek A; Translational Research Center University Hospital of Psychiatry and Psychotherapy University of Bern Bern Switzerland.
  • Velioglu HA; Interdisciplinary Biosciences Doctoral Training Partnership Department of Physiology Anatomy and Genetics University of Oxford Oxford UK.
  • Hanoglu L; Department of Neurology and Neuroscience Alanya Alaaddin Keykubat University Antalya Turkey.
Alzheimers Dement (N Y) ; 10(1): e12450, 2024.
Article en En | MEDLINE | ID: mdl-38356480
ABSTRACT

INTRODUCTION:

Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms.

METHODS:

We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as "amnestic" or "nonamnestic," based on the members' subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.

RESULTS:

The right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.

DISCUSSION:

The pulvinar may play a role in depression-related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Alzheimers Dement (N Y) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Alzheimers Dement (N Y) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos