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Association of region-specific hippocampal reduction of neurogranin with inflammasome proteins in post mortem brains of Alzheimer's disease.
Vontell, Regina T; Gober, Ryan; Dallmeier, Julian; Brzostowicki, Daniel; Barreda, Ayled; Blennow, Kaj; Zetterberg, Henrik; Kvartsberg, Hlin; Gultekin, Sakir Humayun; de Rivero Vaccari, Juan Pablo; Bramlett, Helen M; Dietrich, W Dalton; Keane, Robert W; Davis, David A; Rundek, Tatjana; Sun, Xiaoyan.
Afiliación
  • Vontell RT; Department of Neurology and Evelyn F. McKnight Brain Institute University of Miami Miller School of Medicine Miami Florida USA.
  • Gober R; Brain Endowment Bank University of Miami Miller School of Medicine Miami Florida USA.
  • Dallmeier J; Brain Endowment Bank University of Miami Miller School of Medicine Miami Florida USA.
  • Brzostowicki D; Brain Endowment Bank University of Miami Miller School of Medicine Miami Florida USA.
  • Barreda A; Brain Endowment Bank University of Miami Miller School of Medicine Miami Florida USA.
  • Blennow K; Brain Endowment Bank University of Miami Miller School of Medicine Miami Florida USA.
  • Zetterberg H; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden.
  • Kvartsberg H; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Sahlgrenska University Hospital/Molndal V-huset Molndal Sweden.
  • Gultekin SH; Paris Brain Institute ICM Pitié-Salpêtrière Hospital Sorbonne University Paris France.
  • de Rivero Vaccari JP; Neurodegenerative Disorder Research Center Division of Life Sciences and Medicine and Department of Neurology Institute on Aging and Brain Disorders University of Science and Technology of China and First Affiliated Hospital of USTC Hefei P.R. China.
  • Bramlett HM; Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden.
  • Dietrich WD; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Sahlgrenska University Hospital/Molndal V-huset Molndal Sweden.
  • Keane RW; Department of Neurodegenerative Disease UCL Institute of Neurology London UK.
  • Davis DA; UK Dementia Research Institute at UCL London UK.
  • Rundek T; Hong Kong Center for Neurodegenerative Diseases Hong Kong China.
  • Sun X; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Alzheimers Dement (N Y) ; 10(1): e12444, 2024.
Article en En | MEDLINE | ID: mdl-38356472
ABSTRACT

INTRODUCTION:

Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology.

METHODS:

We investigated the protein expression, morphological differences of Ng, and correlated Ng to hyperphosphorylated tau in the post mortem brains of 17 AD cases and 17 age- and sex-matched controls. In addition, we correlated the Ng expression with two different epitopes of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).

RESULTS:

We show a reduction of Ng immunopositive neurons and morphological differences in AD compared to controls. Ng immunostaining was negatively correlated with neurofibrillary tangles, humanized anti-ASC (IC100) positive neurons and anti-ASC positive microglia, in AD.

DISCUSSION:

The finding of a negative correlation between Ng and ASC speck protein expression in post mortem brains of AD suggests that the activation of inflammasome/ASC speck pathway may play an important role in synaptic degeneration in AD. Highlights We show the role that neurogranin plays on post-synaptic signaling in specific hippocampal regions.We demonstrate that there could be clinical implications of using neurogranin as a biomarker for dementia.We describe the loss of plasticity and neuronal scaffolding proteins in the present of AD pathology.We show the response of neuroinflammation when tau proteins phosphorylate in hippocampal neurons.We show that there is a potential therapeutic target for the inflammasome, and future studies may show that IC100, a humanized monoclonal antibody directed against ASC, may slow the progression of neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Alzheimers Dement (N Y) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Alzheimers Dement (N Y) Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos