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Changes in the expression of satellite glial cell-specific markers during postnatal development of rat sympathetic ganglia.
Nguyen, Huu Son; Kang, Seong Jun; Kim, Sohyun; Cha, Byung Ho; Park, Kyu-Sang; Jeong, Seong-Woo.
Afiliación
  • Nguyen HS; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Kang SJ; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Kim S; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Cha BH; Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Park KS; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea; Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Jeong SW; Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address: swjeong@yonsei.ac.kr.
Brain Res ; 1829: 148809, 2024 Apr 15.
Article en En | MEDLINE | ID: mdl-38354998
ABSTRACT
The sympathetic ganglia represent a final motor pathway that mediates homeostatic "fight and flight" responses in the visceral organs. Satellite glial cells (SGCs) form a thin envelope close to the neuronal cell body and synapses in the sympathetic ganglia. This unique morphological feature suggests that neurons and SGCs form functional units for regulation of sympathetic output. In the present study, we addressed whether SGC-specific markers undergo age-dependent changes in the postnatal development of rat sympathetic ganglia. We found that fatty acid-binding protein 7 (FABP7) is an early SGC marker, whereas the S100B calcium-binding protein, inwardly rectifying potassium channel, Kir4.1 and small conductance calcium-activated potassium channel, SK3 are late SGC markers in the postnatal development of sympathetic ganglia. Unlike in sensory ganglia, FABP7 + SGC was barely detectable in adult sympathetic ganglia. The expression of connexin 43, a gap junction channel gradually increased with age, although it was detected in both SGCs and neurons in sympathetic ganglia. Glutamine synthetase was expressed in sensory, but not sympathetic SGCs. Unexpectedly, the sympathetic SGCs expressed a water-selective channel, aquaporin 1 instead of aquaporin 4, a pan-glial marker. However, aquaporin 1 was not detected in the SGCs encircling large neurons. Nerve injury and inflammation induced the upregulation of glial fibrillary acidic protein, suggesting that this protein is a hall marker of glial activation in the sympathetic ganglia. In conclusion, our findings provide basic information on the in vivo profiles of specific markers for identifying sympathetic SGCs at different stages of postnatal development in both healthy and diseased states.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuroglía / Células Satélites Perineuronales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuroglía / Células Satélites Perineuronales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos