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Microtubule specialization by +TIP networks: from mechanisms to functional implications.
Meier, Sandro M; Steinmetz, Michel O; Barral, Yves.
Afiliación
  • Meier SM; Institute of Biochemistry, Department of Biology, and Bringing Materials to Life Initiative, ETH Zürich, Switzerland; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, Switzerland; Bringing Materials to Life Initiative, ETH Zürich, Switzerland.
  • Steinmetz MO; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen, Switzerland; University of Basel, Biozentrum, CH-4056 Basel, Switzerland. Electronic address: michel.steinmetz@psi.ch.
  • Barral Y; Institute of Biochemistry, Department of Biology, and Bringing Materials to Life Initiative, ETH Zürich, Switzerland; Bringing Materials to Life Initiative, ETH Zürich, Switzerland. Electronic address: yves.barral@bc.biol.ethz.ch.
Trends Biochem Sci ; 49(4): 318-332, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38350804
ABSTRACT
To fulfill their actual cellular role, individual microtubules become functionally specialized through a broad range of mechanisms. The 'search and capture' model posits that microtubule dynamics and functions are specified by cellular targets that they capture (i.e., a posteriori), independently of the microtubule-organizing center (MTOC) they emerge from. However, work in budding yeast indicates that MTOCs may impart a functional identity to the microtubules they nucleate, a priori. Key effectors in this process are microtubule plus-end tracking proteins (+TIPs), which track microtubule tips to regulate their dynamics and facilitate their targeted interactions. In this review, we discuss potential mechanisms of a priori microtubule specialization, focusing on recent findings indicating that +TIP networks may undergo liquid biomolecular condensation in different cell types.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Asociadas a Microtúbulos / Microtúbulos Tipo de estudio: Prognostic_studies Idioma: En Revista: Trends Biochem Sci Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Asociadas a Microtúbulos / Microtúbulos Tipo de estudio: Prognostic_studies Idioma: En Revista: Trends Biochem Sci Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido