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Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Santé cohort.
Sellem, Laury; Srour, Bernard; Javaux, Guillaume; Chazelas, Eloi; Chassaing, Benoit; Viennois, Emilie; Debras, Charlotte; Druesne-Pecollo, Nathalie; Esseddik, Younes; Szabo de Edelenyi, Fabien; Arnault, Nathalie; Agaësse, Cédric; De Sa, Alexandre; Lutchia, Rebecca; Huybrechts, Inge; Scalbert, Augustin; Pierre, Fabrice; Coumoul, Xavier; Julia, Chantal; Kesse-Guyot, Emmanuelle; Allès, Benjamin; Galan, Pilar; Hercberg, Serge; Deschasaux-Tanguy, Mélanie; Touvier, Mathilde.
Afiliación
  • Sellem L; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Srour B; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Javaux G; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Chazelas E; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Chassaing B; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Viennois E; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Debras C; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Druesne-Pecollo N; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Esseddik Y; INSERM U1016, team "Mucosal microbiota in chronic inflammatory diseases", CNRS UMR 8104, Université Paris Cité, Paris, France.
  • Szabo de Edelenyi F; INSERM U1149, Center of Research on Inflammation, Université Paris Cité, Paris, France.
  • Arnault N; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Agaësse C; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • De Sa A; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Lutchia R; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Huybrechts I; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Scalbert A; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Pierre F; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Coumoul X; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Julia C; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Kesse-Guyot E; Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
  • Allès B; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Galan P; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Hercberg S; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
  • Deschasaux-Tanguy M; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
  • Touvier M; Nutrition And Cancer Research Network (NACRe Network), Jouy-en-Josas, France.
PLoS Med ; 21(2): e1004338, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38349899
ABSTRACT

BACKGROUND:

Emulsifiers are widely used food additives in industrially processed foods to improve texture and enhance shelf-life. Experimental research suggests deleterious effects of emulsifiers on the intestinal microbiota and the metabolome, leading to chronic inflammation and increasing susceptibility to carcinogenesis. However, human epidemiological evidence investigating their association with cancer is nonexistent. This study aimed to assess associations between food additive emulsifiers and cancer risk in a large population-based prospective cohort. METHODS AND

FINDINGS:

This study included 92,000 adults of the French NutriNet-Santé cohort without prevalent cancer at enrolment (44.5 y [SD 14.5], 78.8% female, 2009 to 2021). They were followed for an average of 6.7 years [SD 2.2]. Food additive emulsifier intakes were estimated for participants who provided at least 3 repeated 24-h dietary records linked to comprehensive, brand-specific food composition databases on food additives. Multivariable Cox regressions were conducted to estimate associations between emulsifiers and cancer incidence. Overall, 2,604 incident cancer cases were diagnosed during follow-up (including 750 breast, 322 prostate, and 207 colorectal cancers). Higher intakes of mono- and diglycerides of fatty acids (FAs) (E471) were associated with higher risks of overall cancer (HR high vs. low category = 1.15; 95% CI [1.04, 1.27], p-trend = 0.01), breast cancer (HR = 1.24; 95% CI [1.03, 1.51], p-trend = 0.04), and prostate cancer (HR = 1.46; 95% CI [1.09, 1.97], p-trend = 0.02). In addition, associations with breast cancer risk were observed for higher intakes of total carrageenans (E407 and E407a) (HR = 1.32; 95% CI [1.09, 1.60], p-trend = 0.009) and carrageenan (E407) (HR = 1.28; 95% CI [1.06, 1.56], p-trend = 0.01). No association was detected between any of the emulsifiers and colorectal cancer risk. Several associations with other emulsifiers were observed but were not robust throughout sensitivity analyses. Main limitations include possible exposure measurement errors in emulsifiers intake and potential residual confounding linked to the observational design.

CONCLUSIONS:

In this large prospective cohort, we observed associations between higher intakes of carrageenans and mono- and diglycerides of fatty acids with overall, breast and prostate cancer risk. These results need replication in other populations. They provide new epidemiological evidence on the role of emulsifiers in cancer risk. TRIAL REGISTRATION ClinicalTrials.gov NCT03335644.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias de la Mama Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: PLoS Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias de la Mama Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: PLoS Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos