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Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia.
Peltenburg, Puck J; van den Heuvel, Lieke M; Kallas, Dania; Bell, Cheyanne; Denjoy, Isabelle; Behr, Elijah R; Field, Ella; Kammeraad, Janneke A E; Yap, Sing-Chien; Probst, Vincent; Ackerman, Michael J; Blom, Nico A; Wilde, Arthur A M; Clur, Sally-Ann B; van der Werf, Christian.
Afiliación
  • Peltenburg PJ; Deparment of Clinical and Exprimental Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • van den Heuvel LM; Department of Pediatric Cardiology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Kallas D; Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • Bell C; Netherlands Heart Institute, Utrecht, the Netherlands.
  • Denjoy I; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, Canada.
  • Behr ER; Windland Smith Rice Sudden Death Genomics Laboratory, Division of Heart Rhythm Services and Pediatric Cardiology, Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
  • Field E; Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat APHP, Université de Paris, Paris, France.
  • Kammeraad JAE; Cardiovascular Clinical Academic Group and Cardiology Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, St. George's University Hospitals NHS Foundation Trust, Cranmer Terrace, London, UK.
  • Yap SC; Department of Pediatric Cardiology, Great Ormond Street Hospital, London, UK.
  • Probst V; Department of Pediatric Cardiology, Erasmus MC - Sophia, Rotterdam, The Netherlands.
  • Ackerman MJ; Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands.
  • Blom NA; Service de cardiologie, Université de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
  • Wilde AAM; Windland Smith Rice Sudden Death Genomics Laboratory, Division of Heart Rhythm Services and Pediatric Cardiology, Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
  • Clur SB; Department of Pediatric Cardiology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • van der Werf C; Department of Pediatric Cardiology, Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.
Europace ; 26(2)2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38349347
ABSTRACT

AIMS:

In patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare inherited arrhythmia syndrome, arrhythmic events can be prevented by medication and lifestyle recommendations. In patients who experience breakthrough arrhythmic events, non-adherence plays an essential role. We aimed to investigate the incidence and potential reasons for non-adherence to medication and lifestyle recommendations in a large, international cohort of patients with CPVT. METHODS AND

RESULTS:

An online multilingual survey was shared with CPVT patients worldwide by their cardiologists, through peer-recruitment, and on social media from November 2022 until July 2023. Self-reported non-adherence was measured using the validated Medication Adherence Rating Scale (MARS) and a newly developed questionnaire about lifestyle. Additionally, validated questionnaires were used to assess potential reasons for medication non-adherence. Two-hundred-and-eighteen patients completed the survey, of whom 200 (92%) were prescribed medication [122 (61%) female; median age 33.5 years (interquartile range 22-50)]. One-hundred-and-three (52%) were prescribed beta-blocker and flecainide, 85 (43%) beta-blocker, and 11 (6%) flecainide. Thirty-four (17%) patients experienced a syncope, aborted cardiac arrest or appropriate implantable cardioverter defibrillator shock after diagnosis. Nineteen (13.4%) patients were exercising more than recommended. Thirty (15%) patients were non-adherent to medication. Female sex [odds ratio (OR) 3.7, 95% confidence interval (CI) 1.3-12.0, P = 0.019], flecainide monotherapy compared to combination therapy (OR 6.8, 95% CI 1.6-31.0, P = 0.010), and a higher agreement with statements regarding concerns about CPVT medication (OR 1.2, 95% CI 1.1-1.3, P < 0.001) were independently associated with non-adherence.

CONCLUSION:

The significant rate of non-adherence associated with concerns regarding CPVT-related medication, emphasizes the potential for improving therapy adherence by targeted patient education.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flecainida / Taquicardia Ventricular Tipo de estudio: Guideline / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Europace Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flecainida / Taquicardia Ventricular Tipo de estudio: Guideline / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Europace Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido