Your browser doesn't support javascript.
loading
Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1.
Yuan, Zilin; Xiong, Ba; Liu, Lie; Lu, Yifan; Liu, Yueping; Wang, Gang; Qian, Yang; Diao, Bo; Tu, Mingzhong.
Afiliación
  • Yuan Z; Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.
  • Xiong B; Oncology Department, Maoming Hospital of Traditional Chinese Medicine, Maoming, Guangdong, China.
  • Liu L; Oncology Department, Maoming Hospital of Traditional Chinese Medicine, Maoming, Guangdong, China.
  • Lu Y; Applied Mathematics, School of Mathematics and Physics, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.
  • Liu Y; Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.
  • Wang G; Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.
  • Qian Y; Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.
  • Diao B; Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.
  • Tu M; Oncology Department, Maoming Hospital of Traditional Chinese Medicine, Maoming, Guangdong, China.
J Biochem Mol Toxicol ; 38(2): e23656, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38348717
ABSTRACT
Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as circular RNAs (circRNAs) and microRNAs (miRNAs), between different cells. Human umbilical cord-derived mesenchymal stem cells (Hu-MSCs) can migrate to tumor sites and exert complex functions throughout tumor progression. In this study, we successfully isolated Hu-MSCs from human umbilical cords based on their surface marker expression. Hu-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of cholangiocarcinoma (CCA) cells. Furthermore, circ_0037104 was downregulated in CCA and inhibited the proliferation and metastasis of CCA cells. Then, we investigated the effect of Hu-MSC-derived exosomal circ_0037104 on CCA. Circ_0037104 mainly regulates miR-620 and enhances APAF1 expression, inhibiting CCA cell proliferation and metastasis. Overall, Hu-MSC exosomal circ_0037104 contributes to the progression and stemness of CCA cells via miR-620/APAF1. In conclusion, Hu-MSC-derived exosomal circ_0037104 sponges miR-620 directly and negatively targets APAF1 to suppress CCA.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma / MicroARNs / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma / MicroARNs / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos