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Tannin-albumin particles as stable carriers of medicines.
Ohanyan, Nelli; Abelyan, Narek; Manukyan, Arpi; Hayrapetyan, Vardan; Chailyan, Samvel; Tiratsuyan, Susanna; Danielyan, Kristine.
Afiliación
  • Ohanyan N; Institute of Biochemistry named after H Buniatian, NAS RA, Yerevan 0014, Armenia.
  • Abelyan N; Russian-Armenian University, Yerevan 0051, Armenia.
  • Manukyan A; Institute of Biochemistry named after H Buniatian, NAS RA, Yerevan 0014, Armenia.
  • Hayrapetyan V; Institute of Chemical Physics named after A.B. Nalbandyan, NAS RA, Yerevan 0014, Armenia.
  • Chailyan S; Institute of Biochemistry named after H Buniatian, NAS RA, Yerevan 0014, Armenia.
  • Tiratsuyan S; Russian-Armenian University, Yerevan 0051, Armenia.
  • Danielyan K; Institute of Biochemistry named after H Buniatian, NAS RA, Yerevan 0014, Armenia.
Nanomedicine (Lond) ; 19(8): 689-708, 2024 04.
Article en En | MEDLINE | ID: mdl-38348681
ABSTRACT

Background:

The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines.

Methods:

Numerous chromatographic and analytical methods, docking analyses and in vivo testing were applied and used.

Results:

Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of in vivo experiments proved that tannin-albumin particles are more stable than albumin particles.

Conclusion:

Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taninos / Extractos Vegetales Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: Armenia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Taninos / Extractos Vegetales Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: Armenia Pais de publicación: Reino Unido