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Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank.
Lin, Fabin; Shi, Yisen; Zheng, Jiayi; Li, Yueping; Chen, Xuanjie; Zou, Xinyang; Hong, Yi; Chen, Ke; Zeng, Yuqi; Ye, Qinyong; Chen, Xiaochun; Chen, Xinyan; Wang, Yingqing; Cai, Guoen.
Afiliación
  • Lin F; Department of Neurology, Institute of Clinical Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Shi Y; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China.
  • Zheng J; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
  • Li Y; School of Basic Medical Science, Fujian Medical University, Fuzhou, China.
  • Chen X; Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, China.
  • Zou X; Department of Neurology, Institute of Clinical Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Hong Y; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen K; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
  • Zeng Y; School of Basic Medical Science, Fujian Medical University, Fuzhou, China.
  • Ye Q; Department of Neurology, Institute of Clinical Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen X; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China.
  • Chen X; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
  • Wang Y; School of Basic Medical Science, Fujian Medical University, Fuzhou, China.
  • Cai G; Department of Neurology, Institute of Clinical Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Front Aging Neurosci ; 15: 1304629, 2023.
Article en En | MEDLINE | ID: mdl-38348197
ABSTRACT

Objective:

Evidence on the individual and combined relationship of physical activity (PA) and fish oil supplement use on the incidence of Parkinson's disease (PD) risk remains lacking. Materials and

methods:

This UK population-based prospective cohort study, involving 385,275 UK Biobank participants, collected PA and fish oil supplement data via touchscreen questionnaires. Using Cox proportional hazards models and restricted cubic splines to examined the associations between use of fish oil supplements, PA and PD risk.

Results:

During a median 12.52-year follow-up, 2,131 participants incident PD. Analysis showed that fish oil supplement users had a lower PD risk [hazard ratio (HR), 0.89; 95% confidence interval (CI), 0.82-0.98]. The adjusted HRs for the PD incidence were 0.96 (95% CI, 0.95-0.98) for total PA; 0.93 (95% CI, 0.90-0.96) for moderate PA; 0.95 (95% CI, 0.91-0.99) for vigorous PA and 0.93 (95% CI, 0.89-0.98) for walking activity. Significant interactions were found between fish oil supplement use and total PA (P for interaction = 0.011), moderate PA (P for interaction = 0.015), and walking activity (P for interaction = 0.029) in relation to PD incidence.

Conclusion:

Both fish oil supplement use and PA were associated with a reduced risk of PD, and the effect of PA in reducing the risk of PD was more pronounced when fish oil supplement was used.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza