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Excess Mortality in Individuals with Autism Spectrum Disorder: A Population-Based Cohort Study.
Huang, Yu-Hsin; Wu, Shu-I; Lee, Min-Jing; Chen, Yi-Lung; Yang, Yao-Hsu; Kuo, Ting-Yu; Hung, Tai-Hsin; Dewey, Michael E; Stewart, Robert; Chen, Vincent Chin-Hung.
Afiliación
  • Huang YH; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
  • Wu SI; Department of Psychiatry, MacKay Memorial Hospital, Taipei City, Taiwan.
  • Lee MJ; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
  • Chen YL; Department of Psychiatry, MacKay Memorial Hospital, Taipei City, Taiwan.
  • Yang YH; Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan.
  • Kuo TY; School of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Hung TH; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Dewey ME; Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan.
  • Stewart R; Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
  • Chen VC; Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi, Taiwan.
Neuropsychiatr Dis Treat ; 20: 247-255, 2024.
Article en En | MEDLINE | ID: mdl-38348059
ABSTRACT

Purpose:

Autism spectrum disorder (ASD) may be associated with increased mortality, but relevant findings have been inconsistent. The modifying effects of gender and intellectual disability on excess mortality in individuals with ASD are underexplored. Patients and

Methods:

Using Taiwan's National Health Insurance Research Database and the National Death Registry, this population-based cohort study selected the data of 75,946 patients with ASD (ASD cohort) and 75,946 age group-, gender-, and income-matched (11) patients without ASD (non-ASD cohort). Cox proportional hazards models were used to compare mortality rates between the cohorts, and stratified analyses were used to evaluate the influence of gender and intellectual disability on mortality risk.

Results:

The ASD cohort had higher mortality rates for all causes of death than did the non-ASD cohort (adjusted hazard ratio 1.64, 95% confidence interval 1.54-1.75). Comorbid intellectual disability was associated with an increased risk of mortality, and this association was stronger in female patients than in male patients. Moreover, when focusing on deaths from natural causes, we found a significantly higher odds ratio for mortality in the ASD population with ID compared to those without ID.

Conclusion:

ASD is associated with increased mortality, especially among female individuals and those with intellectual disability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Neuropsychiatr Dis Treat Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Neuropsychiatr Dis Treat Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Nueva Zelanda