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Understanding the Mechanisms of Diminished Ovarian Reserve: Insights from Genetic Variants and Regulatory Factors.
Zhu, Qinying; Ma, Hao; Wang, Jing; Liang, Xiaolei.
Afiliación
  • Zhu Q; The First Clinical Medical College of, Lanzhou University, Lanzhou, China.
  • Ma H; The First Clinical Medical College of, Lanzhou University, Lanzhou, China.
  • Wang J; Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, China.
  • Liang X; Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, No.1, Donggangxi Rd, Chengguan District, Lanzhou, 730000, China. liangxl07@lzu.edu.cn.
Reprod Sci ; 31(6): 1521-1532, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38347379
ABSTRACT
Delaying childbearing age has become a trend in modern times, but it has also led to a common challenge in clinical reproductive medicine-diminished ovarian reserve (DOR). Since the mechanism behind DOR is unknown and its clinical features are complex, physicians find it difficult to provide targeted treatment. Many factors affect ovarian reserve function, and existing studies have shown that genetic variants, upstream regulatory genes, and changes in protein expression levels are present in populations with reduced ovarian reserve function. However, existing therapeutic regimens often do not target the genetic profile for more individualized treatment. In this paper, we review the types of genetic variants, mutations, altered expression levels of microRNAs, and other related factors and their effects on the regulation of follicular development, as well as altered DNA methylation. We hope this review will have significant implications for the future treatment of individuals with reduced ovarian reserve.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Reserva Ovárica Límite: Animals / Female / Humans Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Reserva Ovárica Límite: Animals / Female / Humans Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos