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Effects of AIDiet intervention to improve diet quality, immuno-metabolic health in normal and overweight PCOS girls: a pilot study.
Mizgier, Malgorzata; Wieckowska, Barbara; Formanowicz, Dorota; Lombardi, Giovanni; Brozek, Alicja; Nowicki, Marcin; Durkalec-Michalski, Krzysztof; Kedzia, Witold; Jarzabek-Bielecka, Grazyna.
Afiliación
  • Mizgier M; Department of Sports Dietetics, Chair of Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland. mizgier@awf.poznan.pl.
  • Wieckowska B; Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806, Poznan, Poland.
  • Formanowicz D; Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60-806, Poznan, Poland.
  • Lombardi G; Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, 20157, Milan, Italy.
  • Brozek A; Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, 61-871, Poznan, Poland.
  • Nowicki M; Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60-806, Poznan, Poland.
  • Durkalec-Michalski K; Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60-806, Poznan, Poland.
  • Kedzia W; Department of Sports Dietetics, Chair of Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.
  • Jarzabek-Bielecka G; Division of Developmental Gynaecology and Sexology, Department of Gynaecology, Poznan University of Medical Sciences, 60-535, Poznan, Poland.
Sci Rep ; 14(1): 3525, 2024 02 12.
Article en En | MEDLINE | ID: mdl-38347150
ABSTRACT
This study was conducted in two groups of girls with PCOS (polycystic ovary syndrome) categorized as slim (group N) and overweight-to-obese (group Ov/Ob). The study's primary outcome was to assess the impact of a 12-week anti-inflammatory diet (AIDiet) intervention, without energy deficit, on daily diet quality improvement, evaluated according to the KIDMED index. The secondary outcome was improving inflammatory, redox, hormonal, and metabolic statuses. In the study, which was completed by 13 girls from the Ov/Ob group and 19 girls from the N group, a significant improvement in the mean KIDMED score was obtained. Moreover, the intervention significantly improves concentration of total antioxidant capacity (TAC), fasting insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR) index, in the Ov/Ob group, while both groups experienced a reduction in the concentration of interleukin (IL)-1 and IL-6, tumour necrosis factor (TNF-α), and androstenedione. The AIDiet intervention effectively improved the quality of the subjects' diets, which was associated with the improvement of hormonal and immuno-metabolic markers. However, these changes in normal-weight patients were observed regardless of body weight reduction. ClinicalTrials.gov Identifier NCT04738409.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Resistencia a la Insulina Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Resistencia a la Insulina Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido