Your browser doesn't support javascript.
loading
Synbiotic of Pediococcus acidilactici and Inulin Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice.
Wang, Mingzhu; Zhang, Longzhou; Piao, Huiyan; Jin, Yuanming; Cui, Chengdu; Jin, Xin; Cui, Lianhua; Yan, Chunri.
Afiliación
  • Wang M; Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Zhang L; Engineering Research Center of North-East Cold Region Beef Cattle Science & Technology Innovation, Ministry of Education, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Piao H; Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Jin Y; Department of Chemistry, National Demonstration Centre for Experimental Chemistry Education, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Cui C; Department of Animal Science, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Jin X; Engineering Research Center of North-East Cold Region Beef Cattle Science & Technology Innovation, Ministry of Education, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Cui L; Department of Animal Medicine, Yanbian University, Yanji, Jilin 133002, P.R. China.
  • Yan C; Laboratory Animal Center?Yanbian University, Yanji, Jilin 133002, P.R. China.
J Microbiol Biotechnol ; 34(3): 689-699, 2024 Mar 28.
Article en En | MEDLINE | ID: mdl-38346819
ABSTRACT
Colitis is a major gastrointestinal disease that threatens human health. In this study, a synbiotic composed of inulin and Pediococcus acidilactici (P. acidilactici) was investigated for its ability to alleviate dextran sulfate sodium (DSS)-induced colitis. The results revealed that the synbiotic, composed of inulin and P. acidilactici, attenuated the body weight loss and disease activity index (DAI) score in mice with DSS-mediated colitis. Determination of biochemical indicators found that the synbiotic increased anti-oxidation and alleviated inflammation in mice. Additionally, histopathological examination revealed that colonic goblet cell loss and severe mucosal damage in the model group were significantly reversed by the combination of inulin and P. acidilactici. Moreover, synbiotic treatment significantly reduced the levels of IL-1ß, TNF-α, and IL-6 in the serum of mice. Thus, a synbiotic composed of inulin and P. acidilactici has preventive and therapeutic effects on DSSinduced colitis in mice.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis / Simbióticos / Pediococcus acidilactici Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Colitis / Simbióticos / Pediococcus acidilactici Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: