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Chemical profile of the roots of Clausena lansium and their inhibitory effects of the over-activation in BV-2 microglial cells.
Wang, Yingjie; Chen, Gang; Zhou, Di; Xu, Libin; Meng, Qingqi; Lin, Bin; Hao, Jinle; Sun, Fuxin; Hou, Yue; Li, Ning.
Afiliación
  • Wang Y; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016,
  • Chen G; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016,
  • Zhou D; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016,
  • Xu L; College of Life and Health Sciences, Northeastern University, Shenyang, 110004, PR China. Electronic address: 987938272@qq.com.
  • Meng Q; College of Life and Health Sciences, Northeastern University, Shenyang, 110004, PR China. Electronic address: 1014925917@qq.com.
  • Lin B; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: randybinlin@sina.com.
  • Hao J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: 15333570330@163.com.
  • Sun F; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016,
  • Hou Y; College of Life and Health Sciences, Northeastern University, Shenyang, 110004, PR China. Electronic address: houyue@mail.neu.edu.cn.
  • Li N; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016,
Phytochemistry ; 220: 114008, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38346545
ABSTRACT
From the 95% ethanol aqueous extract of the roots of Clausena lansium, six previously undescribed alkaloids (1, 2a, 2b, 15, 24a, 24b), a pair of prenylated phenylpropenols (26a, 26b), two coumarins (27, 28), and two undescribed sesquiterpenes (37, 38) were isolated and identified using spectroscopic and electron circular dichroism data, together with thirty-two known compounds. The absolute configurations of three alkaloids (3a, 3b, 4a) were determined for the first time. In vitro assay showed that alkaloids 7, 10, 12, 19, and furanocoumarins 34, 35 displayed inhibitory effects on the production of nitric oxide in lipopolysaccharide (LPS)-induced BV-2 microglial cells, which were stronger than that of the minocycline (positive control). RT-PCR results indicated that indizoline (7) could inhibit the expression of pro-inflammatory factors (IL-1ß, TNF-α, and IL-6) in LPS-treated BV-2 cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides / Clausena Tipo de estudio: Prognostic_studies Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides / Clausena Tipo de estudio: Prognostic_studies Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido