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Antitumor activity of 5-hydroxy-3',4',6,7-tetramethoxyflavone in glioblastoma cell lines and its antagonism with radiotherapy.
Papapetrou, Panagiota; Dimitriadis, Kyriakos; Galani, Vasiliki; Zoi, Vasiliki; Giannakopoulou, Maria; Papathanasopoulou, Vasiliki A; Sioka, Chrissa; Tsekeris, Pericles; Kyritsis, Athanassios P; Lazari, Diamanto; Alexiou, George A.
Afiliación
  • Papapetrou P; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
  • Dimitriadis K; Laboratory of Pharmacognosy, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Galani V; Department of Anatomy Histology-Embryology, School of Medicine, University of Ioannina, Ioannina, Greece.
  • Zoi V; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
  • Giannakopoulou M; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
  • Papathanasopoulou VA; Department of Radiation Oncology, University of Ioannina, Ioannina, Greece.
  • Sioka C; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
  • Tsekeris P; Department of Radiation Oncology, University of Ioannina, Ioannina, Greece.
  • Kyritsis AP; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
  • Lazari D; Laboratory of Pharmacognosy, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Alexiou GA; Neurosurgical Institute, University of Ioannina, Ioannina, Greece.
Biomol Concepts ; 15(1)2024 Jan 01.
Article en En | MEDLINE | ID: mdl-38345457
ABSTRACT
5-Hydroxy-3',4',6,7-tetramethoxyflavone (TMF) is a plant-origin flavone known for its anti-cancer properties. In the present study, the cytotoxic effect of TMF was evaluated in the U87MG and T98G glioblastoma (GBM) cell lines. The effect of TMF on cell viability was assessed with trypan blue exclusion assay and crystal violet staining. In addition, flow cytometry was performed to examine its effect on the different phases of the cell cycle, and in vitro scratch wound assay assessed the migratory capacity of the treated cells. Furthermore, the effect of in vitro radiotherapy was also evaluated with a combination of TMF and radiation. In both cell lines, TMF treatment resulted in G0/G1 cell cycle arrest, reduced cell viability, and reduced cell migratory capacity. In contrast, there was an antagonistic property of TMF treatment with radiotherapy. These results demonstrated the antineoplastic effect of TMF in GBM cells in vitro, but the antagonistic effect with radiotherapy indicated that TMF should be further evaluated for its possible antitumor role post-radiotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Límite: Humans Idioma: En Revista: Biomol Concepts Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Límite: Humans Idioma: En Revista: Biomol Concepts Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania