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Influencing factors of clinical efficacy of roxadustat among hemodialysis patients.
Wu, Wenhui; Hu, Nan; Li, Xiurong; Di, Jia; Zhou, Hua; Niu, Hongyan; Yang, Min.
Afiliación
  • Wu W; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Hu N; Department of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Li X; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Di J; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Zhou H; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Niu H; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Yang M; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Ren Fail ; 46(1): 2308701, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38345059
ABSTRACT

OBJECTIVE:

To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients.

METHODS:

Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A multiple logistic regression model was established to determine the factors that affect clinical efficacy of roxadustat in patients undergoing hemodialysis.

RESULTS:

A total of 67 hemodialysis patients were enrolled in the study. The results showed that age, blood trough concentration of roxadustat, and baseline hemoglobin (Hb) level were independent factors of clinical efficacy of roxadustat (OR = 1.06, p = .025 for age; OR = 1.001, p = .037 for plasma concentration; and OR = 0.941, p = .003 for baseline Hb), with an AUC score of 0.859.

CONCLUSIONS:

Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Espectrometría de Masas en Tándem Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Espectrometría de Masas en Tándem Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido