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Venoarterial extracorporeal membrane oxygenation for vasoplegic shock after treprostinil refill of an implanted intravenous pump: a case report.
Valencia, Lucía; López, Sergio; Olivas, Ana; Becerra, Ángel; Alemán-Segura, María Desirée; Évora-García, Marta; Ojeda, Nazario; Cabrera, Leonardo; Rodríguez-Pérez, Aurelio; Pérez-Peñate, Gregorio.
Afiliación
  • Valencia L; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • López S; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • Olivas A; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • Becerra Á; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • Alemán-Segura MD; Department of Medical and Surgical Sciences, University of Las Palmas de Gran Canaria, Gran Canaria, Spain.
  • Évora-García M; Multidisciplinary Pulmonary Vascular Unit, Department of Respiratory Medicine, Hospital Universitario Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
  • Ojeda N; Multidisciplinary Pulmonary Vascular Unit, Department of Respiratory Medicine, Hospital Universitario Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
  • Cabrera L; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • Rodríguez-Pérez A; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
  • Pérez-Peñate G; Department of Anesthesiology and Intensive Care, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Front Cardiovasc Med ; 11: 1348311, 2024.
Article en En | MEDLINE | ID: mdl-38343873
ABSTRACT

Introduction:

Venoarterial extracorporeal membrane oxygenation (ECMO) is a rescue therapy that can stabilize patients with hemodynamic compromise. Indications continue to evolve, including drug overdose. However, the indication merely for vasoplegic shock following drug overdose is controversial. Case

summary:

We report a case of a 57-year-old male with high-risk idiopathic pulmonary arterial hypertension treated with upfront triple combination therapy (sildenafil, bosentan, and intravenous treprostinil infusion via subcutaneous abdominal implantable pump). In one of the refills of the drug reservoir, accidental administration of 1 months's supply of treprostinil (200 mg) into the subcutaneous tissue occurred, causing refractory vasoplegic shock. He required urgent VA-ECMO for 96 h, surviving to discharge 28 days later.

Discussion:

Treprostinil poisoning is rare due to its less frequent use but is life-threatening. ECMO may be considered in vasoplegic shock due to overdose of vasodilatory medication. It allows organ perfusion to be maintained, with the knowledge that recovery is as rapid as drug elimination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza