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Development and Validation of a 3D Resnet Model for Prediction of Lymph Node Metastasis in Head and Neck Cancer Patients.
Lin, Yi-Hui; Lin, Chieh-Ting; Chang, Ya-Han; Lin, Yen-Yu; Chen, Jen-Jee; Huang, Chun-Rong; Hsu, Yu-Wei; You, Weir-Chiang.
Afiliación
  • Lin YH; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung City, Taiwan.
  • Lin CT; College of Artificial Intelligence, National Yang-Ming Chiao Tung University, Hsinchu City, Taiwan.
  • Chang YH; Department of Computer Science, National Yang-Ming Chiao Tung University, Hsinchu City, Taiwan.
  • Lin YY; Department of Computer Science, National Yang-Ming Chiao Tung University, Hsinchu City, Taiwan.
  • Chen JJ; College of Artificial Intelligence, National Yang-Ming Chiao Tung University, Hsinchu City, Taiwan.
  • Huang CR; Academy of Innovative Semiconductor and Sustainable Manufacturing, National Cheng Kung University, Tainan City, Taiwan.
  • Hsu YW; Cancer Prevention and Control Center, Taichung Veterans General Hospital, Taichung City, Taiwan.
  • You WC; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung City, Taiwan. bigjohnyou@vghtc.gov.tw.
J Imaging Inform Med ; 37(2): 679-687, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38343258
ABSTRACT
The accurate diagnosis and staging of lymph node metastasis (LNM) are crucial for determining the optimal treatment strategy for head and neck cancer patients. We aimed to develop a 3D Resnet model and investigate its prediction value in detecting LNM. This study enrolled 156 head and neck cancer patients and analyzed 342 lymph nodes segmented from surgical pathologic reports. The patients' clinical and pathological data related to the primary tumor site and clinical and pathology T and N stages were collected. To predict LNM, we developed a dual-pathway 3D Resnet model incorporating two Resnet models with different depths to extract features from the input data. To assess the model's performance, we compared its predictions with those of radiologists in a test dataset comprising 38 patients. The study found that the dimensions and volume of LNM + were significantly larger than those of LNM-. Specifically, the Y and Z dimensions showed the highest sensitivity of 84.6% and specificity of 72.2%, respectively, in predicting LNM + . The analysis of various variations of the proposed 3D Resnet model demonstrated that Dual-3D-Resnet models with a depth of 34 achieved the highest AUC values of 0.9294. In the validation test of 38 patients and 86 lymph nodes dataset, the 3D Resnet model outperformed both physical examination and radiologists in terms of sensitivity (80.8% compared to 50.0% and 91.7%, respectively), specificity(90.0% compared to 88.5% and 65.4%, respectively), and positive predictive value (77.8% compared to 66.7% and 55.0%, respectively) in detecting individual LNM + . These results suggest that the 3D Resnet model can be valuable for accurately identifying LNM + in head and neck cancer patients. A prospective trial is needed to evaluate further the role of the 3D Resnet model in determining LNM + in head and neck cancer patients and its impact on treatment strategies and patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Imaging Inform Med Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Imaging Inform Med Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza