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Determination of Inducible Clindamycin Resistance and Correlation with Vitek2 Inducible Clindamycin Resistance Test in Staphylococcus aureus Isolated from Clinical Samples.
Zafar, Adeel; Khursheed, Nazia; Adnan, Fareeha; Zahid, Qurat Ul Ain.
Afiliación
  • Zafar A; Department of Pathology (Microbiology), Indus Hospital and Health Network, Karachi, Pakistan.
  • Khursheed N; Department of Pathology (Microbiology), Indus Hospital and Health Network, Karachi, Pakistan.
  • Adnan F; Department of Pathology (Microbiology), Indus Hospital and Health Network, Karachi, Pakistan.
  • Zahid QUA; Department of Pathology (Microbiology), Indus Hospital and Health Network, Karachi, Pakistan.
J Coll Physicians Surg Pak ; 34(2): 183-186, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38342869
ABSTRACT

OBJECTIVE:

To compare the performance of Vitek2 with the gold standard D test in terms of inducible clindamycin resistance (ICR) detection. STUDY

DESIGN:

Descriptive study. Place and Duration of the Study Indus Hospital and Health Network Karachi, Pakistan, from November 2021 to April 2022.

METHODOLOGY:

Standard operating procedures of the laboratory were followed for processing of clinical samples. Methicillin-resistant Staphylococcus aureus (MRSA) isolates were included. The isolates from the same patient within two-week time period were excluded. Clinical laboratory standards institute guidelines were followed for performing and interpreting D test. The results of the D test were compared with Vitek2 results for ICR.

RESULTS:

A total of 313 isolates were MRSA, of which 93 isolates tested positive for ICR on both the D test and Vitek2. Nine isolates were positive for ICR on Vitek2 and negative on the Kirby-Bauer disk diffusion method. One isolate tested positive on the disk method and negative on Vitek2.

CONCLUSION:

Vitek 2 appeared to give false positive results. Reporting false susceptibility of clindamycin can cause therapeutic failure which can markedly affect the patient's outcome. This discordance needs to be investigated further with a large sample size and stringent observation of D-test results to pick laboratory error. KEY WORDS Methicillin-resistant Staphylococcus aureus, Inducible clindamycin resistance, D zone, Vitek2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: J Coll Physicians Surg Pak Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: J Coll Physicians Surg Pak Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán