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Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia.
Aref, Salah; Khaled, Omnyia; Menshawy, Nadia El; Azmy, Emad; Aref, Mohamed; Salama, Osama; Khaled, Nada.
Afiliación
  • Aref S; Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt. salaharef@yahoo.com.
  • Khaled O; Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
  • Menshawy NE; Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
  • Azmy E; Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Aref M; Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Salama O; Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
  • Khaled N; Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
J Egypt Natl Canc Inst ; 36(1): 5, 2024 Feb 12.
Article en En | MEDLINE | ID: mdl-38342816
ABSTRACT

OBJECTIVE:

This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.

METHODS:

SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

RESULTS:

Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

CONCLUSION:

Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: J Egypt Natl Canc Inst Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: J Egypt Natl Canc Inst Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido