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Predicting suicidal ideation using multiple serum biomarkers in patients with acute coronary syndrome.
Kim, Jae-Min; Kim, Ju-Wan; Kang, Hee-Ju; Choi, Wonsuk; Lee, Ju-Yeon; Kim, Sung-Wan; Shin, Il-Seon; Ahn, Youngkeun; Jeong, Myung Ho.
Afiliación
  • Kim JM; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea. Electronic address: jmkim@chonnam.ac.kr.
  • Kim JW; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kang HJ; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Choi W; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Republic of Korea.
  • Lee JY; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim SW; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Shin IS; Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Ahn Y; Department of Cardiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Jeong MH; Department of Cardiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
J Affect Disord ; 351: 915-919, 2024 Apr 15.
Article en En | MEDLINE | ID: mdl-38342323
ABSTRACT

BACKGROUND:

Biomarkers for suicidal behavior in patients with acute coronary syndrome (ACS) have yet to be elucidated. This study aimed to identify a panel of serum biomarkers associated with suicidal ideation (SI) in patients with ACS.

METHODS:

The study evaluated 969 patients within 2 weeks of ACS (acute phase) and 711 patients 12 months later (chronic phase). The evaluation included 14 serum biomarkers covering 7 functional systems, socio-demographic/clinical characteristics, and SI assessed by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. Logistic regression models were used to analyze the data. The results showed that 195 patients (20.1 %) had SI in the acute phase, and 87 patients (12.2 %) had SI in the chronic phase.

RESULTS:

A combination of five serum biomarkers (tumor necrosis factor-α, interleukin-1ß, folate, troponin I, and creatine kinase-MB) was significantly associated with SI in the acute phase, and a combination of three serum biomarkers (tumor necrosis factor-α, interleukin-1ß, and folate) was significantly associated with SI in the chronic phase in a clear dose-dependent manner (all P-values < 0.001) after adjustment for relevant covariates.

DISCUSSION:

These findings suggest that the application of a combination of multiple serum biomarkers could improve the predictability of SI in patients with ACS at both acute and chronic phases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Ideación Suicida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Ideación Suicida Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos