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Construction and validation of a nomogram to predict left ventricular hypertrophy in low-risk patients with hypertension.
Zhang, Xueyao; He, Chuan; Lu, Saien; Yu, Haijie; Li, Guangxiao; Zhang, Pengyu; Sun, Yingxian.
Afiliación
  • Zhang X; Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
  • He C; Department of Laboratory Medicine, First Hospital of China Medical University, Shenyang, China.
  • Lu S; National Clinical Research Center for Laboratory Medicine Center, First Hospital of China Medical University, Shenyang, China.
  • Yu H; Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
  • Li G; Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
  • Zhang P; Department of Medical Record Management Center, First Hospital of China Medical University, Shenyang, China.
  • Sun Y; Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
J Clin Hypertens (Greenwich) ; 26(3): 274-285, 2024 03.
Article en En | MEDLINE | ID: mdl-38341620
ABSTRACT
Electrocardiography (ECG) is an accessible diagnostic tool for screening patients with hypertensive left ventricular hypertrophy (LVH). However, its diagnostic sensitivity is low, with a high probability of false-negatives. Thus, this study aimed to establish a clinically useful nomogram to supplement the assessment of LVH in patients with hypertension and without ECG-LVH based on Cornell product criteria (low-risk hypertensive population). A cross-sectional dataset was used for model construction and divided into development (n = 2906) and verification (n = 1447) datasets. A multivariable logistic regression risk model and nomogram were developed after screening for risk factors. Of the 4353 low-risk hypertensive patients, 673 (15.4%) had LVH diagnosed by echocardiography (Echo-LVH). Eleven risk factors were identified hypertension awareness, duration of hypertension, age, sex, high waist-hip ratio, education level, tea consumption, hypochloremia, and other ECG-LVH diagnostic criteria (including Sokolow-Lyon, Sokolow-Lyon products, and Peguero-Lo Presti). For the development and validation datasets, the areas under the curve were 0.724 (sensitivity = 0.606) and 0.700 (sensitivity = 0.663), respectively. After including blood pressure, the areas under the curve were 0.735 (sensitivity = 0.734) and 0.716 (sensitivity = 0.718), respectively. This novel nomogram had a good predictive ability and may be used to assess the Echo-LVH risk in patients with hypertension and without ECG-LVH based on Cornell product criteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos