[Corticosteroids and metabolic resuscitation (hydrocortisone, ascorbic acid and thiamine) in sepsis and septic shock]. / Corticoides y resucitación metabólica (hidrocortisona, ácido ascórbico y tiamina) en la sepsis y el shock séptico.
Med Intensiva (Engl Ed)
; 46 Suppl 1: 49-59, 2022 Apr.
Article
en Es
| MEDLINE
| ID: mdl-38341260
ABSTRACT
In accordance with the recommendations of, among others, the Surviving Sepsis Campaign, adjunctive therapies may play a role in the treatment and the prognosis in sepsis patients. Corticosteroids, ascorbic acid, and thiamine has been identified as a potential therapy for septic shock alone or in combination. Since many years, low-dosis corticosteroids has been proposed as adjuvant therapies for these patients. However, there are still many controversies regarding the role of systemic low-dose corticosteroids as a part of the treatment of septic shock. In recent clinical and experimental investigations, mitochondrion-target therapy bic acid and thiamine) for sepsis has been suggested to reduce MODS severity and mortality although their clinical results are not yet convincing for their use. In the present article, we have performed a narrative review of the current literature including pathophysiologic rationale and the current evidence for such therapies in septic patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Guideline
Idioma:
Es
Revista:
Med Intensiva (Engl Ed)
Año:
2022
Tipo del documento:
Article
Pais de publicación:
España