Your browser doesn't support javascript.
loading
Larger hypothalamic subfield volumes in patients with chronic insomnia disorder and relationships to levels of corticotropin-releasing hormone.
Luo, Yucai; Yu, Liyong; Zhang, Pan; Lin, Wenting; Xu, Hao; Dou, Zeyang; Zhao, Guangli; Peng, Wei; Zeng, Fang; Yu, Siyi.
Afiliación
  • Luo Y; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Yu L; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhang P; Nervous System Disease Treatment Center, Traditional Chinese Medicine Hospital of Meishan, Meishan, China.
  • Lin W; School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Xu H; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Dou Z; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Zhao G; School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Peng W; Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
  • Zeng F; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Acupuncture and Brain Science Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Yu S; School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Acupuncture and Brain Science Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: siyi_yu@cdutcm.edu.cn.
J Affect Disord ; 351: 870-877, 2024 Apr 15.
Article en En | MEDLINE | ID: mdl-38341156
ABSTRACT
The hypothalamus is a well-established core structure in the sleep-wake cycle. While previous studies have not consistently found whole hypothalamus volume changes in chronic insomnia disorder (CID), differences may exist at the smaller substructural level of the hypothalamic nuclei. The study aimed to investigate the differences in total and subfield hypothalamic volumes, between CID patients and healthy controls (HCs) in vivo, through an advanced deep learning-based automated segmentation tool. A total of 150 patients with CID and 155 demographically matched HCs underwent T1-weighted structural magnetic resonance scanning. We utilized FreeSurfer v7.2 for automated segmentation of the hypothalamus and its five nuclei. Additionally, correlation and causal mediation analyses were performed to investigate the association between hypothalamic volume changes, insomnia symptom severity, and hypothalamus-pituitary-adrenal (HPA) axis-related blood biomarkers. CID patients exhibited larger volumes in the right anterior inferior, left anterior superior, and left posterior subunits of the hypothalamus compared to HCs. Moreover, we observed a positive association between blood corticotropin-releasing hormone (CRH) levels and insomnia severity, with anterior inferior hypothalamus (a-iHyp) hypertrophy mediating this relationship. In conclusion, we found significant volume increases in several hypothalamic subfield regions in CID patients, highlighting the central role of the HPA axis in the pathophysiology of insomnia.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Liberadora de Corticotropina / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Liberadora de Corticotropina / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos