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Expression levels of ADAMTS 5, 9, and 12 in endometrial polyps and their predictive value for the diagnosis and recurrence of endometrial polyps.
Nian, Jiejie; Zhu, Yuqing; Lv, Xiaoli; Zhang, Yue; Xue, Zhongkai; Wu, Zhongran; Zhou, Yujia; Liu, Yu.
Afiliación
  • Nian J; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China; Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui
  • Zhu Y; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China; Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui
  • Lv X; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China; Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui
  • Zhang Y; Department of Gynecology and Obstetrics, Xuancheng City People's Hospital, Xuancheng, Anhui, 242000, China.
  • Xue Z; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China; Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui
  • Wu Z; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China.
  • Zhou Y; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China.
  • Liu Y; Department of Gynecology and Obstetrics, Maternity and Child Healthcare Hospital Affiliated to Anhui Medical University, Hefei Maternal and Child Health Hospital, Hefei, Anhui 230001, China; Department of Gynecology and Obstetrics, The Fifth Clinical College of Anhui Medical University, Hefei, Anhui
Eur J Obstet Gynecol Reprod Biol ; 295: 86-91, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38340595
ABSTRACT

PURPOSE:

Endometrial polyps (EPs) are common gynecological disorders for which no clear etiology has been found. ADAMTS have been associated with a variety of diseases. This study aimed to investigate the potential correlation between serologic levels of ADAMTS 5, 9, and 12 in patients with EPs.

METHODS:

A total of 88 patients were categorized into two groups the EPs group, consisting of recurrent EPs and first occurrence EPs, and a control group. The study compared the general information and serum levels of ADAMTS 5, 9, and 12 between the groups.

RESULTS:

Regarding the general data, a statistically significant age difference (p < 0.05) was observed, while no significant differences were found in the other variables. After considering age as a confounding factor, the previously observed statistical significance in the differences of ADAMTS5 and 9 between the groups diminished. However, it was found that the concentrations of ADAMTS12 in both the EPs group and the recurrent EPs group were significantly higher compared to the control group and the first occurrence EPs group (p < 0.05). ROC curves were generated to determine the critical values of ADAMTS12 for predicting EPs and recurrent EPs, which were found to be 0.6962 ng/ml (sensitivity 100 %, specificity 39.5 %) and 0.8768 ng/ml (sensitivity 75.0 %, specificity 76.3 %), respectively.

CONCLUSION:

Our findings revealed elevated serologic levels of ADAMTS12 in the EPs group, particularly in the recurrent EPs group. Furthermore, ADAMTS-12 was identified as a valuable biomarker for assisting in the diagnosis and prediction of EPs recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pólipos / Enfermedades de los Genitales Femeninos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pólipos / Enfermedades de los Genitales Femeninos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda