Your browser doesn't support javascript.
loading
Oxidative Damage of DNA, Proteins and C-Reactive Protein Parameters in Girls and Boys with Exogenous Constitutional Obesity.
Darenskaya, M A; Rychkova, L V; Kolesnikov, S I; Semenova, N V; Nikitina, O A; Lesnaya, A S; Kolesnikova, L I.
Afiliación
  • Darenskaya MA; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. marina_darenskaya@inbox.ru.
  • Rychkova LV; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
  • Kolesnikov SI; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
  • Semenova NV; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
  • Nikitina OA; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
  • Lesnaya AS; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
  • Kolesnikova LI; Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med ; 176(3): 328-331, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38340194
ABSTRACT
The parameters of oxidative damage of DNA, proteins, as well as the parameters of the thiol-disulfide system and C-reactive protein in adolescent girls and boys with exogenous constitutional obesity (ECO) were evaluated. In girls and boys with obesity, the levels of 8-hydroxy-2'-deoxyguanosine (marker of DNA destruction) were higher than in controls. Evaluation of the activity of the thiol-disulfide system revealed increased levels of oxidized glutathione (GSSG) and decreased levels of the reduced glutathione (GSH) and GSSG ratio (GSH/GSSG) in adolescents with ECO regardless of the sex in comparison with the control. C-reactive protein was also higher in the ECO groups regardless of the sex. The levels of glutathione peroxidase in obese boys were higher than in girls. In view of the revealed shifts, corrective measures with the prescription of drugs with antioxidant properties are recommended in adolescents with ECO to stabilize the indices.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Estrés Oxidativo Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Bull Exp Biol Med Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Estrés Oxidativo Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Bull Exp Biol Med Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos