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Investigating the impact of the genetic variant CXCR1 (rs2234671) in individuals with urinary tract infections.
Naser, Hassan Hachim; Kadhim, Mohanad Jawad; Almhanna, Hazem.
Afiliación
  • Naser HH; Zoonotic Disease Research Unit, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
  • Kadhim MJ; Department of Medical Biotechnology, College of Biotechnology, Al-Qasim Green University, Babylon, Iraq.
  • Almhanna H; Department of Anatomy, Histology and Embryology, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
Hum Antibodies ; 32(1): 9-18, 2024.
Article en En | MEDLINE | ID: mdl-38339925
ABSTRACT

BACKGROUND:

Urinary tract infections (UTIs) are currently posing a worldwide health concern by affecting millions of people. The genetic variant rs2234671 in the CXCR1-interleukin-8 receptor is closely related to a raised UTI risk.

OBJECTIVES:

In this work, the impact of CXCR1 (rs2234671) on UTI individuals was examined.

METHODS:

The demographic features of 30 recurrent UTI patients and 20 controls were thoroughly investigated. Bacterial isolation and identification were performed by the implementation of cultural and biochemical methods. DNA extraction, purification of all samples from both patients and healthy people, and IL-8 rs2234671 (C/G) SNP genotyping using T-ARMS-PCR were performed. The significance of the results was evaluated by carrying out a statistical analysis.

FINDINGS:

The patient's average age was 34.63 ± 11.44 years, and controls averaged 30.30 ± 8.59 years (P= 0.156). No significant gender difference existed (P= 0.804). Escherichia coli (63.3%) was predominant, followed by Proteus mirabilis (26.7%), Enterococcus faecalis (23.3%), Klebsiella pneumoniae (10.0%), and Pseudomonas aeruginosa (20.0%). No significant association was found between bacterial species frequency, age, or sex. From the CXCR1 (rs2234671) frequency comparison, a higher GG genotype incidence in UTI patients than controls was extracted (26.7% vs. 15.0%), though not statistically significant. Risk analysis revealed that GG homozygous and C/G heterozygous genotypes were not UTI risk factors (OR = 2.47 and OR = 1.85, respectively). Moreover, the allele frequencies displayed no significant difference between the patients and controls (G allele 66.7% vs. 66.7%; C allele 33.3% vs. 33.3%). MAIN

CONCLUSIONS:

Although no significant association between CXCR1 (rs2234671) and UTI was found, the GG genotype may point to the increasing probability of UTI risk. Additional research is required to confirm and expand these conclusions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Hum Antibodies Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Urinarias Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Hum Antibodies Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Países Bajos