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Intraoral Ultrasound versus MRI for Depth of Invasion Measurement in Oral Tongue Squamous Cell Carcinoma: A Prospective Diagnostic Accuracy Study.
Kaltoft, Mikkel; Hahn, Christoffer Holst; Wessman, Marcus; Hansen, Martin Lundsgaard; Agander, Tina Klitmøller; Makouei, Fatemeh; Wessel, Irene; Todsen, Tobias.
Afiliación
  • Kaltoft M; Department of Oto-Rhino-Laryngology, Head- and Neck Surgery and Audiology Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Hahn CH; Department of Oto-Rhino-Laryngology, Head- and Neck Surgery and Audiology Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Wessman M; Institute of Clinical Medicine, Faculty of Health Sciences, Copenhagen University, 2200 Copenhagen, Denmark.
  • Hansen ML; Department of Oto-Rhino-Laryngology, Head- and Neck Surgery and Audiology Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Agander TK; Department of Radiology, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Makouei F; Department of Pathology, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Wessel I; Department of Oto-Rhino-Laryngology, Head- and Neck Surgery and Audiology Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Todsen T; Institute of Clinical Medicine, Faculty of Health Sciences, Copenhagen University, 2200 Copenhagen, Denmark.
Cancers (Basel) ; 16(3)2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38339388
ABSTRACT
Oral squamous cell carcinoma (OSCC) of the tongue is the most common type of oral cavity cancer, and tumor depth of invasion (DOI) is an important prognostic factor. In this study, we investigated the accuracy of intraoral ultrasound and magnetic resonance imaging (MRI) for assessing DOI in patients with OSCC. Histopathological measurement of DOI was used as a reference standard. We conducted a prospective study including patients planned for surgical treatment of OSCC in the tongue. The DOI was measured in an outpatient setting by intraoral ultrasound and MRI, and was compared to the histopathological DOI measurements. Bland-Altman analysis compared the mean difference and 95% limits of agreement (LOA) for ultrasound and MRI, and the Wilcoxon signed-rank test was used to test for significance. The correlation was evaluated using Pearson's correlation coefficient. We included 30 patients 26 with T1 or T2 tumors, and 4 with T3 tumors. The mean difference from histopathology DOI was significantly lower for ultrasound compared to MRI (0.95 mm [95% LOA -4.15 mm to 6.06 mm] vs. 1.90 mm [95% LOA -9.02 mm and 12.81 mm], p = 0.023). Ultrasound also led to significantly more correct T-stage classifications in 86.7% (26) of patients compared to 56.7% (17) for MRI, p = 0.015. The Pearson correlation between MRI and histopathology was 0.57 (p < 0.001) and the correlation between ultrasound and histopathology was 0.86 (p < 0.001). This prospective study found that intraoral ultrasound is more accurate than MRI in assessing DOI and for the T-staging of oral tongue cancers. Clinical practice and guidelines should implement intraoral ultrasound accordingly.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza