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Y-Box-Binding Proteins Have a Dual Impact on Cellular Translation.
Eliseeva, Irina A; Buyan, Andrey I; Smolin, Egor A; Kaliadzenka, Karina S; Popov, Sergey; Kulakovskiy, Ivan V; Lyabin, Dmitry N.
Afiliación
  • Eliseeva IA; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
  • Buyan AI; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
  • Smolin EA; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
  • Kaliadzenka KS; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
  • Popov S; Endocrinology Research Center, Moscow 117036, Russia.
  • Kulakovskiy IV; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
  • Lyabin DN; Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
Int J Mol Sci ; 25(3)2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38339016
ABSTRACT
Y-box-binding proteins (YB proteins) are multifunctional DNA- and RNA-binding proteins that play an important role in the regulation of gene expression. The high homology of their cold shock domains and the similarity between their long, unstructured C-terminal domains suggest that Y-box-binding proteins may have similar functions in a cell. Here, we consider the functional interchangeability of the somatic YB proteins YB-1 and YB-3. RNA-seq and Ribo-seq are used to track changes in the mRNA abundance or mRNA translation in HEK293T cells solely expressing YB-1, YB-3, or neither of them. We show that YB proteins have a dual effect on translation. Although the expression of YB proteins stimulates global translation, YB-1 and YB-3 inhibit the translation of their direct CLIP-identified mRNA targets. The impact of YB-1 and YB-3 on the translation of their mRNA targets is similar, which suggests that they can substitute each other in inhibiting the translation of their mRNA targets in HEK293T cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza