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Broccoli Cultivated with Deep Sea Water Mineral Fertilizer Enhances Anti-Cancer and Anti-Inflammatory Effects of AOM/DSS-Induced Colorectal Cancer in C57BL/6N Mice.
Lee, Yeon-Jun; Pan, Yanni; Lim, Daewoo; Park, Seung-Hwan; Sin, Sin-Il; Kwack, KyuBum; Park, Kun-Young.
Afiliación
  • Lee YJ; Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea.
  • Pan Y; Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea.
  • Lim D; Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea.
  • Park SH; Agriculture Research Center for Carbon Neutral and Healing, Gurye-gun 57607, Republic of Korea.
  • Sin SI; Agriculture Research Center for Carbon Neutral and Healing, Gurye-gun 57607, Republic of Korea.
  • Kwack K; Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea.
  • Park KY; Graduate School of Integrative Medicine, CHA University, Seongnam 13488, Republic of Korea.
Int J Mol Sci ; 25(3)2024 Jan 29.
Article en En | MEDLINE | ID: mdl-38338927
ABSTRACT
This study aimed to determine the alleviating effect of broccoli grown with deep sea water mineral (DSWM) fertilizer extracted from deep sea water on the development of colorectal cancer in C57BL/6N mice treated with AOM/DSS. Naturaldream Fertilizer Broccoli (NFB) cultured with deep sea water minerals (DSWM) showed a higher antioxidant effect and mineral content. In addition, orally administered NFB, showed a level of recovery in the colon and spleen tissues of mice compared with those in normal mice through hematoxylin and eosin (H&E) staining. Orally administered NFB showed the inhibition of the expression of inflammatory cytokine factors IL-1ß, IL-6, TNF, IFN-γ, and IL-12 while increasing the expression of IL-10. Furthermore, the expression of inflammatory cytokines and NF-κB in the liver tissue was inhibited, and that of inflammatory enzymes, such as COX-2 and iNOS, was reduced. In the colon tissue, the expression of p53 and p21 associated with cell cycle arrest increased, and that of Bcl-2 associated with apoptosis decreased. Additionally, the expression of Bax, Bad, Bim, Bak, caspase 9, and caspase 3 increased, indicating enhanced activation of apoptosis-related factors. These results demonstrate that oral administration of broccoli cultivated using DSWM significantly restores spleen and colon tissues and simultaneously inhibits the NF-κB pathway while significantly decreasing cytokine expression. Moreover, by inducing cell cycle arrest and activating cell apoptosis, they also suggest alleviating AOM/DSS-induced colon cancer symptoms in C57BL/6N mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Brassica / Colitis / Neoplasias del Colon Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Brassica / Colitis / Neoplasias del Colon Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Suiza