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Phytochemical Elucidation and Effect of Maesa indica (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats.
Abdelgawad, Fatma Alzahra M; El-Hawary, Seham S; El-Kader, Essam M Abd; Alshehri, Saad Ali; Rabeh, Mohamed Abdelaaty; El-Mosallamy, Aliaa E M K; Salama, Abeer; El Gedaily, Rania A.
Afiliación
  • Abdelgawad FAM; Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University El Salam City, Cairo 11785, Egypt.
  • El-Hawary SS; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza 11562, Egypt.
  • El-Kader EMA; Department of Timber Trees Research, Horticultural Research Institute (ARC), Giza 12619, Egypt.
  • Alshehri SA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62251, Saudi Arabia.
  • Rabeh MA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62251, Saudi Arabia.
  • El-Mosallamy AEMK; Department of Pharmacology, National Research Centre, Cairo 12622, Egypt.
  • Salama A; Department of Pharmacology, National Research Centre, Cairo 12622, Egypt.
  • El Gedaily RA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza 11562, Egypt.
Plants (Basel) ; 13(3)2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38337870
ABSTRACT
Maesa indica (Roxb.) Sweet is one of the well-known traditionally-used Indian plants. This plant is rich in secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, saponins, and carbohydrates. It contains numerous therapeutically active compounds like palmitic acid, chrysophanol, glyceryl palmitate, stigmasterol, ß-sitosterol, dodecane, maesaquinone, quercetin 3-rhaminoside, rutin, chlorogenic acid, catechin, quercetin, nitrendipine, 2,3-dihydroxypropyl octadeca-9,12-dienoate, kiritiquinon, and ß-thujone. The Maesa indica plant has been reported to have many biological properties including antidiabetic, anticancer, anti-angiogenic, anti-leishmanial, antioxidant, radical scavenging, antibacterial, antiviral, and anti-coronavirus effects. One purpose of the current study was to investigate the leaves' metabolome via Triple-Time-of-Flight-Liquid-Chromatography-Mass Spectrometry (T-TOF LC/MS/MS) to identify the chemical constituents of the Maesa indica ethanolic extract (ME). Another purpose of this study was to explore the protective effect of ME against potassium dichromate (PD)-induced pulmonary damage in rats. Rats were assigned randomly into four experimental groups. Two different doses of the plant extract, (25 and 50 mg/kg), were administered orally for seven consecutive days before PD instillation injection. Results of our study revealed that ME enhanced cellular redox status as it decreased lipid peroxidation marker, MDA and elevated reduced glutathione (GSH). In addition, ME upregulated the cytoprotective signaling pathway PI3K/AKT. Moreover, ME administration ameliorated histopathological anomalies induced by PD. Several identified metabolites, such as chlorogenic acid, quercetin, apigenin, kaempferol, luteolin, and rutin, had previously indicated lung-protective effects, possibly through an antioxidant effect and inhibition of oxidative stress and inflammatory mediators. In conclusion, our results indicated that ME possesses lung-protective effects, which may be the result of its antioxidant and anti-inflammatory properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Suiza