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Early Extra-Uterine Growth Restriction in Very-Low-Birth-Weight Neonates with Normal or Mildly Abnormal Brain MRI: Effects on a 2-3-Year Neurodevelopmental Outcome.
Massirio, Paolo; Battaglini, Marcella; Bonato, Irene; De Crescenzo, Sara; Calevo, Maria Grazia; Malova, Mariya; Caruggi, Samuele; Parodi, Alessandro; Preiti, Deborah; Zoia, Agata; Uccella, Sara; Tortora, Domenico; Severino, Mariasavina; Rossi, Andrea; Traggiai, Cristina; Nobili, Lino; Striano, Pasquale; Ramenghi, Luca Antonio.
Afiliación
  • Massirio P; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Battaglini M; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Bonato I; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy.
  • De Crescenzo S; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Calevo MG; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Malova M; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy.
  • Caruggi S; Epidemiology and Biostatistic Unit, Scientific Direction, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Parodi A; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Preiti D; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Zoia A; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy.
  • Uccella S; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Tortora D; Psychology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Severino M; Neonatal Intensive Care Unit, Maternal and Neonatal Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Rossi A; Psychology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Traggiai C; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy.
  • Nobili L; Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Striano P; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  • Ramenghi LA; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Nutrients ; 16(3)2024 Feb 03.
Article en En | MEDLINE | ID: mdl-38337733
ABSTRACT
Extra-uterine growth restriction (EUGR) is a common complication and a known risk factor for impaired development in very-low-birth-weight (VLBW) neonates. We report a population of 288 patients with no or with low-grade MRI lesions scanned at a term equivalent age (TEA) born between 2012 and 2018. Griffiths Mental Development Scale II (GMDS II) at 2 and 3 years, preterm complications and weight growth were retrospectively analyzed. EUGR was defined for weight z-score ˂ 10 percentile at TEA, 6 and 12 months of correct age or as z-score decreased by 1-point standard deviation (SDS) from birth to TEA and from TEA to 6 months. Multivariate analysis showed that a higher weight z-score at 6 months is protective for the global developmental quotient (DQ) at 2 years (OR 0.74; CI 95% 0.59-0.93; p = 0.01). EUGR at 6 months was associated with worse locomotor, personal/social, language and performance DQ at 2 years and worse language and practical reasoning DQ at 3 years. In conclusion, a worse weight z-score at 6 months of age seems to be an independent risk factor for significantly reduced GMDS in many areas. These results suggest that we should invest more into post-discharge nutrition, optimizing family nutritional education.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Cuidados Posteriores Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Cuidados Posteriores Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza