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Biochemical Profiling of Urine Metabolome in Premature Infants Based on LC-MS Considering Maternal Influence.
Mok, Jeong-Hun; Song, Junhwan; Hahn, Won-Ho; Cho, Seonghyeon; Park, Jong-Moon; Koh, Jiwon; Kim, Ho; Kang, Nam Mi.
Afiliación
  • Mok JH; Department of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul 06355, Republic of Korea.
  • Song J; Department of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
  • Hahn WH; Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.
  • Cho S; Basil Biotech, Incheon 22002, Republic of Korea.
  • Park JM; Basil Biotech, Incheon 22002, Republic of Korea.
  • Koh J; Department of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
  • Kim H; Department of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
  • Kang NM; Department of Nursing, Research Institute for Biomedical & Health Science, Konkuk University, Chungju-si 27478, Republic of Korea.
Nutrients ; 16(3)2024 Jan 31.
Article en En | MEDLINE | ID: mdl-38337695
ABSTRACT
In this study, Liquid Chromatography-Mass Spectrometry (LC-MS)-based metabolomics profiling was conducted to elucidate the urinary profiles of premature infants during early and late postnatal stages. As a result, we discovered significant excretion of maternal drugs in early-stage infants and identified crucial metabolites like hormones and amino acids. These findings shed light on the maternal impact on neonatal metabolism and underscore the beneficial effects of breastfeeding on the metabolism of essential amino acids in infants. This research not only enhances our understanding of maternal-infant nutritional interactions and their long-term implications for preterm infants but also offers critical insights into the biochemical characteristics and physiological mechanisms of preterm infants, laying a groundwork for future clinical studies focused on neonatal development and health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Cromatografía Líquida con Espectrometría de Masas Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Cromatografía Líquida con Espectrometría de Masas Tipo de estudio: Prognostic_studies Límite: Female / Humans / Infant / Newborn Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article Pais de publicación: Suiza