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Long-Term Kinetics of SARS-CoV-2 Neutralizing and Anti-Receptor Binding Domain Antibodies among Laboratory-Confirmed COVID-19 Cases in Delhi National Capital Region, India: A Prospective, One-Year Follow-Up Study.
Misra, Puneet; Medigeshi, Guruprasad R; Kant, Shashi; Jaiswal, Abhishek; Ahmad, Mohammad; Rahman, Anisur; Guleria, Randeep; Rai, Sanjay Kumar; Deori, Trideep Jyoti; Mandal, Suprakash; Gongal, Gaurav; Bairwa, Mohan; Haldar, Partha; Kumar, Rakesh; Garg, Neha.
Afiliación
  • Misra P; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Medigeshi GR; Translational Health Science and Technology Institute, Faridabad 121001, India.
  • Kant S; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Jaiswal A; Employee State Insurance Corporation Medical College & Hospital, Faridabad 121001, India.
  • Ahmad M; WHO Country Office, New Delhi 110011, India.
  • Rahman A; WHO Country Office, New Delhi 110011, India.
  • Guleria R; Institute of Internal Medicine & Respiratory and Sleep Medicine, Medanta, Gurugram 122001, India.
  • Rai SK; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Deori TJ; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Mandal S; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Gongal G; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Bairwa M; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Haldar P; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Kumar R; Centre for Community Medicine, Old OT-Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Garg N; Translational Health Science and Technology Institute, Faridabad 121001, India.
J Clin Med ; 13(3)2024 Jan 29.
Article en En | MEDLINE | ID: mdl-38337457
ABSTRACT

Background:

This study was conducted with the objective of measuring the neutralizing and anti-receptor binding domain antibody levels against SARS-CoV-2 among laboratory-confirmed COVID-19 cases and exploring its long-term kinetics over a period of 1 year.

Methods:

One hundred laboratory-confirmed COVID-19 cases were recruited. Serum samples of the participants were collected within three months from the date of the positive COVID-19 report. The participants were prospectively followed up every three months for symptoms and the collection of blood samples for three additional rounds. The presence of anti-SARS-CoV-2 antibodies (IgA, IgG, and IgM antibodies), anti-receptor binding domain antibodies (anti-RBD), and neutralizing antibodies were measured.

Findings:

Median plaque reduction neutralization test (PRNT) titers showed a rising trend in the first three rounds of follow-up. The quantitative anti-receptor binding domain ELISA (QRBD) values showed a declining trend in the initial three rounds. However, both the PRNT titers and QRBD values showed significantly higher values for the fourth round of follow-up. Total antibody (WANTAI) levels showed an increasing trend in the initial three rounds (statistically significant).

Interpretation:

Neutralizing antibodies showed an increasing trend. The anti-receptor binding domain antibodies showed a decreasing trend. Neutralizing antibodies and anti-RBD antibodies persisted in the majority.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza