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Melanoma biology and treatment: a review of novel regulated cell death-based approaches.
Hsieh, Ming-Yun; Hsu, Sheng-Kai; Liu, Tzu-Yu; Wu, Chang-Yi; Chiu, Chien-Chih.
Afiliación
  • Hsieh MY; Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Hsu SK; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan.
  • Liu TY; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
  • Wu CY; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
  • Chiu CC; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan. cywu@mail.nsysu.edu.tw.
Cancer Cell Int ; 24(1): 63, 2024 Feb 09.
Article en En | MEDLINE | ID: mdl-38336727
ABSTRACT
The incidence of melanoma, the most lethal form of skin cancer, has increased due to ultraviolet exposure. The treatment of advanced melanoma, particularly metastatic cases, remains challenging with poor outcomes. Targeted therapies involving BRAF/MEK inhibitors and immunotherapy based on anti-PD1/anti-CTLA4 antibodies have achieved long-term survival rates of approximately 50% for patients with advanced melanoma. However, therapy resistance and inadequate treatment response continue to hinder further breakthroughs in treatments that increase survival rates. This review provides an introduction to the molecular-level pathogenesis of melanoma and offers an overview of current treatment options and their limitations. Cells can die by either accidental or regulated cell death (RCD). RCD is an orderly cell death controlled by a variety of macromolecules to maintain the stability of the internal environment. Since the uncontrolled proliferation of tumor cells requires evasion of RCD programs, inducing the RCD of melanoma cells may be a treatment strategy. This review summarizes studies on various types of nonapoptotic RCDs, such as autophagy-dependent cell death, necroptosis, ferroptosis, pyroptosis, and the recently discovered cuproptosis, in the context of melanoma. The relationships between these RCDs and melanoma are examined, and the interplay between these RCDs and immunotherapy or targeted therapy in patients with melanoma is discussed. Given the findings demonstrating melanoma cell death in response to different stimuli associated with these RCDs, the induction of RCD shows promise as an integral component of treatment strategies for melanoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Cell Int Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Cell Int Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido