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Selective Induction of Molecular Assembly to Tissue-Level Anisotropy on Peptide-Based Optoelectronic Cardiac Biointerfaces.
Yao, Ze-Fan; Kuang, Yuyao; Wu, Hao-Tian; Lundqvist, Emil; Fu, Xin; Celt, Natalie; Pei, Jian; Yee, Albert F; Ardoña, Herdeline Ann M.
Afiliación
  • Yao ZF; Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
  • Kuang Y; Department of Chemistry, School of Physical Sciences, University of California, Irvine, CA, 92697, USA.
  • Wu HT; Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
  • Lundqvist E; Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center of Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
  • Fu X; Department of Biomedical Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
  • Celt N; Department of Materials Science and Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
  • Pei J; Department of Biomedical Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
  • Yee AF; Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center of Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
  • Ardoña HAM; Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Irvine, CA, 92697, USA.
Adv Mater ; 36(21): e2312231, 2024 May.
Article en En | MEDLINE | ID: mdl-38335948
ABSTRACT
The conduction efficiency of ions in excitable tissues and of charged species in organic conjugated materials both benefit from having ordered domains and anisotropic pathways. In this study, a photocurrent-generating cardiac biointerface is presented, particularly for investigating the sensitivity of cardiomyocytes to geometrically comply to biomacromolecular cues differentially assembled on a conductive nanogrooved substrate. Through a polymeric surface-templated approach, photoconductive substrates with symmetric peptide-quaterthiophene (4T)-peptide units assembled as 1D nanostructures on nanoimprinted polyalkylthiophene (P3HT) surface are developed. The 4T-based peptides studied here can form 1D nanostructures on prepatterned polyalkylthiophene substrates, as directed by hydrogen bonding, aromatic interactions between 4T and P3HT, and physical confinement on the nanogrooves. It is observed that smaller 4T-peptide units that can achieve a higher degree of assembly order within the polymeric templates serve as a more efficient driver of cardiac cytoskeletal anisotropy than merely presenting aligned -RGD bioadhesive epitopes on a nanotopographic surface. These results unravel some insights on how cardiomyocytes perceive submicrometer dimensionality, local molecular order, and characteristics of surface cues in their immediate environment. Overall, the work offers a cardiac patterning platform that presents the possibility of a gene modification-free cardiac photostimulation approach while controlling the conduction directionality of the biotic and abiotic components.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Miocitos Cardíacos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Miocitos Cardíacos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania