Your browser doesn't support javascript.
loading
Breast Cancer Detection Using a Low-Dose Positron Emission Digital Mammography System.
Freitas, Vivianne; Li, Xuan; Scaranelo, Anabel; Au, Frederick; Kulkarni, Supriya; Ghai, Sandeep; Taeb, Samira; Bubon, Oleksandr; Baldassi, Brandon; Komarov, Borys; Parker, Shayna; Macsemchuk, Craig A; Waterston, Michael; Olsen, Kenneth O; Reznik, Alla.
Afiliación
  • Freitas V; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Li X; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Scaranelo A; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Au F; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Kulkarni S; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Ghai S; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Taeb S; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Bubon O; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Baldassi B; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Komarov B; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Parker S; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Macsemchuk CA; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Waterston M; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Olsen KO; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
  • Reznik A; From the Temerty Faculty of Medicine, Joint Department of Medical Imaging, University Health Network, Sinai Health System, Women's College Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9 (V.F., A.S., F.A., S.K., S.G.); Department of Biostatistics, Princess Margaret C
Radiol Imaging Cancer ; 6(2): e230020, 2024 03.
Article en En | MEDLINE | ID: mdl-38334470
ABSTRACT
Purpose To investigate the feasibility of low-dose positron emission mammography (PEM) concurrently to MRI to identify breast cancer and determine its local extent. Materials and Methods In this research ethics board-approved prospective study, participants newly diagnosed with breast cancer with concurrent breast MRI acquisitions were assigned independently of breast density, tumor size, and histopathologic cancer subtype to undergo low-dose PEM with up to 185 MBq of fluorine 18-labeled fluorodeoxyglucose (18F-FDG). Two breast radiologists, unaware of the cancer location, reviewed PEM images taken 1 and 4 hours following 18F-FDG injection. Findings were correlated with histopathologic results. Detection accuracy and participant details were examined using logistic regression and summary statistics, and a comparative analysis assessed the efficacy of PEM and MRI additional lesions detection (ClinicalTrials.gov NCT03520218). Results Twenty-five female participants (median age, 52 years; range, 32-85 years) comprised the cohort. Twenty-four of 25 (96%) cancers (19 invasive cancers and five in situ diseases) were identified with PEM from 100 sets of bilateral images, showcasing comparable performance even after 3 hours of radiotracer uptake. The median invasive cancer size was 31 mm (range, 10-120). Three additional in situ grade 2 lesions were missed at PEM. While not significant, PEM detected fewer false-positive additional lesions compared with MRI (one of six [16%] vs eight of 13 [62%]; P = .14). Conclusion This study suggests the feasibility of a low-dose PEM system in helping to detect invasive breast cancer. Though large-scale clinical trials are essential to confirm these preliminary results, this study underscores the potential of this low-dose PEM system as a promising imaging tool in breast cancer diagnosis. ClinicalTrials.gov registration no. NCT03520218 Keywords Positron Emission Digital Mammography, Invasive Breast Cancer, Oncology, MRI Supplemental material is available for this article. © RSNA, 2024 See also commentary by Barreto and Rapelyea in this issue.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Aspecto: Ethics Límite: Female / Humans / Middle aged Idioma: En Revista: Radiol Imaging Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Aspecto: Ethics Límite: Female / Humans / Middle aged Idioma: En Revista: Radiol Imaging Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos