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Correlation Between C-Reactive Protein and Lipid Analytes in Dry Age-Related Macular Degeneration: A Retrospective Study.
Sannan, Naif S; Elsayid, Mohieldin; Alsharif, Ghadi; Ramadan, Majed; Alhalwani, Amani Y; Qahwaji, Rowaid M; Arbaeen, Ahmad; Aalam, Waseem A; Alqahtani, Abdullah S; Talat, Karim.
Afiliación
  • Sannan NS; Department of Clinical Laboratory Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
  • Elsayid M; Department of Biomedical Research, King Abdullah International Medical Research Center, Jeddah, SAU.
  • Alsharif G; Department of Clinical Laboratory Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
  • Ramadan M; Department of Clinical Laboratory Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
  • Alhalwani AY; Department of Biomedical Research, King Abdullah International Medical Research Center, Jeddah, SAU.
  • Qahwaji RM; Department of Clinical Laboratory Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
  • Arbaeen A; Department of Biomedical Research, King Abdullah International Medical Research Center, Jeddah, SAU.
  • Aalam WA; Department of Clinical Laboratory, King Abdulaziz University, Jeddah, SAU.
  • Alqahtani AS; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, SAU.
  • Talat K; Department of Ophthalmology, College of Medicine, University of Jeddah, Jeddah, SAU.
Cureus ; 16(1): e51935, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38333436
ABSTRACT

INTRODUCTION:

To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD.

METHODS:

A standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls.

RESULTS:

The study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson's correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP.

CONCLUSION:

Our findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos