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Enhancing cognitive control with transcranial magnetic stimulation in subject-specific frontoparietal networks.
Dengler, Julia; Deck, Benjamin L; Stoll, Harrison; Fernandez-Nunez, Guadalupe; Kelkar, Apoorva S; Rich, Ryan R; Erickson, Brian A; Erani, Fareshte; Faseyitan, Olufunsho; Hamilton, Roy H; Medaglia, John D.
Afiliación
  • Dengler J; School of Biomedical Engineering Science and Health Systems, Drexel University, Philadelphia, PA, USA.
  • Deck BL; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Stoll H; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Fernandez-Nunez G; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Kelkar AS; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Rich RR; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Erickson BA; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Erani F; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA.
  • Faseyitan O; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  • Hamilton RH; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  • Medaglia JD; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jdm582@drexel.edu.
Cortex ; 172: 141-158, 2024 03.
Article en En | MEDLINE | ID: mdl-38330778
ABSTRACT

BACKGROUND:

Cognitive control processes, including those involving frontoparietal networks, are highly variable between individuals, posing challenges to basic and clinical sciences. While distinct frontoparietal networks have been associated with specific cognitive control functions such as switching, inhibition, and working memory updating functions, there have been few basic tests of the role of these networks at the individual level.

METHODS:

To examine the role of cognitive control at the individual level, we conducted a within-subject excitatory transcranial magnetic stimulation (TMS) study in 19 healthy individuals that targeted intrinsic ("resting") frontoparietal networks. Person-specific intrinsic networks were identified with resting state functional magnetic resonance imaging scans to determine TMS targets. The participants performed three cognitive control tasks an adapted Navon figure-ground task (requiring set switching), n-back (working memory), and Stroop color-word (inhibition).

OBJECTIVE:

Hypothesis:

We predicted that stimulating a network associated with externally oriented control [the "FPCN-B" (fronto-parietal control network)] would improve performance on the set switching and working memory task relative to a network associated with attention (the Dorsal Attention Network, DAN) and cranial vertex in a full within-subjects crossover design.

RESULTS:

We found that set switching performance was enhanced by FPCN-B stimulation along with some evidence of enhancement in the higher-demand n-back conditions.

CONCLUSION:

Higher task demands or proactive control might be a distinguishing role of the FPCN-B, and personalized intrinsic network targeting is feasible in TMS designs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Magnética Transcraneal / Memoria a Corto Plazo Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cortex Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Magnética Transcraneal / Memoria a Corto Plazo Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cortex Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Italia