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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine.
Zhong, Yi; Li, Xin-Yue; Liang, Tian-Jun; Ding, Bao-Zhu; Ma, Ke-Xin; Ren, Wen-Xuan; Liang, Wen-Jie.
Afiliación
  • Zhong Y; College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney Diseases, Institute of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, 050200, Chin
  • Li XY; Department of Cardiovascular Internal Medicine, the Second Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi Province, 332000, China.
  • Liang TJ; Graduate School, Hebei Medical University, Shijiazhuang, 050017, China.
  • Ding BZ; Graduate School, Hebei Medical University, Shijiazhuang, 050017, China.
  • Ma KX; Rural Physician College, Hebei Medical University, Shijiazhuang, 050017, China.
  • Ren WX; Medical Department, the First Hospital of Hebei Medical University, Shijiazhuang, 050030, China.
  • Liang WJ; Graduate School, Hebei Medical University, Shijiazhuang, 050017, China.
Chin J Integr Med ; 30(5): 468-479, 2024 May.
Article en En | MEDLINE | ID: mdl-38329654
ABSTRACT
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases (CVDs), such as diabetic cardiomyopathy, ischemia/reperfusion injury, myocardial infarction, heart failure and hypertension. Noncoding RNAs (ncRNAs) are important regulatory factors. Many Chinese medicine (CM) compounds, including their effective components, can regulate pyroptosis and exert myocardium-protecting effects. The mechanisms underlying this protection include inhibition of inflammasome protein expression, Toll-like receptor 4-NF-κB signal pathway activation, oxidative stress, endoplasmic reticulum stress (ERS), and mixed lineage kinase 3 expression and the regulation of silent information regulator 1. The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM. Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inflamasomas / Piroptosis / Medicina Tradicional China Límite: Animals / Humans Idioma: En Revista: Chin J Integr Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inflamasomas / Piroptosis / Medicina Tradicional China Límite: Animals / Humans Idioma: En Revista: Chin J Integr Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article Pais de publicación: China